Literature DB >> 6869120

Determination of submicrogram quantities of cimetidine and its biotransformation and degradation products.

B Jenko, A Kosak, D Milivojevic, B Kralj.   

Abstract

The new and convenient method for the separation, isolation and characterization of the N-ciano-N'-methyl-N"-(2-/(5-methylimidazol-4-yl)methylthio/ethyl) guanidine and its biotransformation and degradation products was developed. Mass spectra obtained with the FAB (Fast Atom Bombardment) method are described. This method proved to be very successful for the analysis and characterization of studied compounds.

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Year:  1983        PMID: 6869120     DOI: 10.1007/bf01967324

Source DB:  PubMed          Journal:  Agents Actions        ISSN: 0065-4299


  3 in total

1.  High-pressure liquid chromatographic analysis of cimetidine, a histamine H2-receptor antagonist, in blood and urine.

Authors:  W C Randolph; V L Osborne; S S Walkenstein; A P Intoccia
Journal:  J Pharm Sci       Date:  1977-08       Impact factor: 3.534

2.  Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine.

Authors:  G J Durant; J C Emmett; C R Ganellin; P D Miles; M E Parsons; H D Prain; G R White
Journal:  J Med Chem       Date:  1977-07       Impact factor: 7.446

3.  High-pressure liquid chromatographic determination of cimetidine sulphoxide in human blood and urine.

Authors:  R M Lee; P M Osborne
Journal:  J Chromatogr       Date:  1978-09-01
  3 in total

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