Literature DB >> 19614

High-pressure liquid chromatographic analysis of cimetidine, a histamine H2-receptor antagonist, in blood and urine.

W C Randolph, V L Osborne, S S Walkenstein, A P Intoccia.   

Abstract

A method is described for extraction of cimetidine, a histamine H2-receptor antagonist, from whole blood and urine with subsequent analysis by high-pressure liquid chromatography (HPLC). The drug is extracted from biological fluids with 1-octanol and back-extracted into dilute acid and then into a small volume of ethanol by saturation with potassium carbonate. HPLC analysis is performed on a column of 5-micrometer silica with a mixed mobile phase consisting primarily of acetonitrile. The method measures concentrations of cimetidine as low as 0.05 microgram/ml and is reproducible. Blood levels and urinary excretion data obtained with the analytical procedure are given for a group of human subjects who received 200-mg oral doses of cimetidine.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 19614     DOI： 10.1002/jps.2600660825

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  45 in total

Review 1.  Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part II).

Authors:  K Lauritsen; L S Laursen; J Rask-Madsen
Journal:  Clin Pharmacokinet       Date:  1990-08       Impact factor: 6.447

2.  Effects on cimetidine bioavailability of metoclopramide and antacids given two hours apart.

Authors:  N Barzaghi; F Crema; G Mescoli; E Perucca
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

3.  Cimetidine or propantheline combined with antacid therapy for short-term treatment of duodenal ulcer.

Authors:  H O Adami; O Björklund; L K Enander; S Gustavsson; L Lööf; A Nordahl; A Rosén
Journal:  Dig Dis Sci       Date:  1982-05       Impact factor: 3.199

4.  Feasibility of biowaiver extension to biopharmaceutics classification system class III drug products: cimetidine.

Authors:  Ekarat Jantratid; Sompol Prakongpan; Gordon L Amidon; Jennifer B Dressman
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

5.  Evaluation of two equivalent regimens (BID, QID) of cimetidine to raise intragastric pH over a 24-hour period in patients with duodenal ulcer.

Authors:  K Shiratori; S Watanabe; T Takeuchi
Journal:  Dig Dis Sci       Date:  1986-11       Impact factor: 3.199

6.  Cimetidine-a clinical and pharmacokinetic study.

Authors:  J Webster; H E Barber; G M Hawksworth; T A Jeffers; J Petersen; J C Petrie; P W Brunt; N A Mowat; R Griffiths
Journal:  Br J Clin Pharmacol       Date:  1981-04       Impact factor: 4.335

7.  Cimetidine pharmacokinetics and dosage requirements in children.

Authors:  A Somogyi; M Becker; R Gugler
Journal:  Eur J Pediatr       Date:  1985-05       Impact factor: 3.183

8.  Human placental transport of cimetidine.

Authors:  S Schenker; J Dicke; R F Johnson; L L Mor; G I Henderson
Journal:  J Clin Invest       Date:  1987-11       Impact factor: 14.808

9.  Does smoking interfere with the effect of histamine H2-receptor antagonists on intragastric acidity in man?

Authors:  P Bauerfeind; T Cilluffo; C J Fimmel; C Emde; C von Ritter; W Kohler; R Gugler; T Gasser; A L Blum
Journal:  Gut       Date:  1987-05       Impact factor: 23.059

10.  Effect of aluminium phosphate on the bioavailability of cimetidine and prednisolone.

Authors:  H Albin; G Vincon; F Demotes-Mainard; B Begaud; A Bedjaoui
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.