Lymph node proliferation in patients with urological tumours.

Reactivity of regional lymph node cells was determined in 87 patients with urological cancer by measuring the S-phases of the cell cycle using flow cytophotometry. Compared with a control group of 28 individuals with and without infectious disease regional to the extirpated lymph nodes, analysis of 250 lymph nodes in tumour patients exhibited either normal, reduced, or elevated S-phases. No relation could be established between the reduced or elevated pattern of reactivity of regional lymph node cells and any known tumour parameter, such as organ manifestation, histology, stage, and grade. Whether the determined S-phases correlate with the prognosis remains to be determined.