Literature DB >> 686812

Psoralen/UVA treatment and chromosomes. II. Analyses of psoriasis patients.

A Brøgger, H Waksvik, P Thune.   

Abstract

Five psoriasis patients treated with 8-methoxypsoralen and UVA (PUVA) were studied by lymphocyte cultures at the 1st, 5th, 10th and 20th treatment and at a maintenance treatment 6 months later. Abnormal amounts of chromosome aberrations were not found, and the frequency of sister chromatid exchange (examined at the last treatment) was not increased. In vitro experiments with nanogram doses of psoralen (similar to plasma levels in patients) showed no increase in chromosome aberration or SCE freqency. The results indicate that therapeutic doses of PUVA have no clastogenic effect.

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Year:  1978        PMID： 686812     DOI： 10.1007/BF00455298

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  23 in total

1.  PSORALEN PROPHYLAXIS AGAINST SKIN CANCER: REPORT OF CLINICAL TRIAL II.

Authors:  C E HOPKINS; J C BELISARIO; E J MACDONALD; C T DAVIS
Journal:  J Invest Dermatol       Date:  1963-10       Impact factor: 8.551

2.  Erythema and tumor formation in methoxsalen-treated mice exposed to flourescent light.

Authors:  R E HAKIM; A C GRIFFIN; J M KNOX
Journal:  Arch Dermatol       Date:  1960-10

3.  The effect of oxypsoralen upon ultraviolet carcinogenesis in albino mice.

Authors:  M A O'NEAL; A C GRIFFIN
Journal:  Cancer Res       Date:  1957-10       Impact factor: 12.701

4.  Induction of multinucleate cells by 8-MOP and UV treatment in vitro and in vivo.

Authors:  A Omar; U N Wiesmann; A Krebs
Journal:  Dermatologica       Date:  1977

5.  Psoralen/UVA treatment and chromosomes. I. Aberrations and sister chromatid exchange in human lymphocytes in vitro and synergism with caffeine.

Authors:  H Waksvik; A Brogger; J Stene
Journal:  Hum Genet       Date:  1977-09-22       Impact factor: 4.132

6.  A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents.

Authors:  M S Sasaki; A Tonomura
Journal:  Cancer Res       Date:  1973-08       Impact factor: 12.701

7.  Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light.

Authors:  J A Parrish; T B Fitzpatrick; L Tanenbaum; M A Pathak
Journal:  N Engl J Med       Date:  1974-12-05       Impact factor: 91.245

8.  Chromosomal abnormalities produced by folic acid antagonists.

Authors:  T J Ryan; M M Boddington; A I Spriggs
Journal:  Br J Dermatol       Date:  1965-11       Impact factor: 9.302

9.  Apparently spontaneous chromosome damage in human leukocytes and the nature of chromatid gaps.

Authors:  A Brogger
Journal:  Humangenetik       Date:  1971

10.  8-methoxypsoralen and UVA promote sister-chromatid exchanges.

Authors:  D M Carter; K Wolff; W Schnedl
Journal:  J Invest Dermatol       Date:  1976-10       Impact factor: 8.551
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  2 in total

1.  [DNA-repair of lymphocytes during PUVA-treatment (author's transl)].

Authors:  E Bohnert; W G Humbel
Journal:  Arch Dermatol Res       Date:  1980       Impact factor: 3.017

Review 2.  Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing.

Authors:  E Gebhart
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132
  2 in total

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