Literature DB >> 686239

The antileishmanial activity of lepidines.

K E Kinnamon, E A Steck, P S Loizeaux, W L Hanson, W L Chapman, V B Waits.   

Abstract

A series of lepidines (6-methoxy-4-methyl-8-aminoquinoline derivatives) was studied in a hamster-Leishmania donovani model. Members of this class were found to have activity many-fold that of the standard, meglumine antimoniate (Glucantime). One of them, 8-(6-diethylamino-hexylamino)-6-methoxy-4-methylquinoline, designated WR 6026, when given orally was over 700 times as effective as the standard antimonial drug.

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Year:  1978        PMID： 686239     DOI： 10.4269/ajtmh.1978.27.751

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  13 in total

Review 1.  Drug resistance in leishmaniasis.

Authors:  Simon L Croft; Shyam Sundar; Alan H Fairlamb
Journal:  Clin Microbiol Rev       Date:  2006-01       Impact factor: 26.132

2.  Potential use of WR6026 as prophylaxis against transfusion-transmitted American trypanosomiasis.

Authors:  E Chiari; A B Oliveira; M A Prado; R J Alves; L M Galvão; F G Araujo
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

3.  Investigational drugs for visceral leishmaniasis.

Authors:  Shyam Sundar; Jaya Chakravarty
Journal:  Expert Opin Investig Drugs       Date:  2014-11-20       Impact factor: 6.206

4.  Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major.

Authors:  José Ignacio Manzano; Luis Carvalho; José M Pérez-Victoria; Santiago Castanys; Francisco Gamarro
Journal:  Antimicrob Agents Chemother       Date:  2011-01-03       Impact factor: 5.191

5.  2-substituted quinoline alkaloids as potential antileishmanial drugs.

Authors:  A Fournet; A A Barrios; V Muñoz; R Hocquemiller; A Cavé; J Bruneton
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

6.  Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds.

Authors:  Jair L Siqueira-Neto; Ok-Ryul Song; Hyunrim Oh; Jeong-Hun Sohn; Gyongseon Yang; Jiyoun Nam; Jiyeon Jang; Jonathan Cechetto; Chang Bok Lee; Seunghyun Moon; Auguste Genovesio; Eric Chatelain; Thierry Christophe; Lucio H Freitas-Junior
Journal:  PLoS Negl Trop Dis       Date:  2010-05-04

7.  Chemotherapy of Babesia microti infections in Mongolian Jirds.

Authors:  T K Ruebush; P G Contacos; E A Steck
Journal:  Antimicrob Agents Chemother       Date:  1980-08       Impact factor: 5.191

8.  Suppression of both antimony-susceptible and antimony-resistant Leishmania donovani by a bis(benzyl)polyamine analog.

Authors:  R J Baumann; W L Hanson; P P McCann; A Sjoerdsma; A J Bitonti
Journal:  Antimicrob Agents Chemother       Date:  1990-05       Impact factor: 5.191

9.  Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani.

Authors:  M Chen; S B Christensen; T G Theander; A Kharazmi
Journal:  Antimicrob Agents Chemother       Date:  1994-06       Impact factor: 5.191

10.  Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes.

Authors:  Carmen López-Martín; José María Pérez-Victoria; Luis Carvalho; Santiago Castanys; Francisco Gamarro
Journal:  Antimicrob Agents Chemother       Date:  2008-09-15       Impact factor: 5.191
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