Literature DB >> 6861869

Relationships between plasma theophylline clearance, liver volume and body weight in children and adults.

J J Grygiel, H Ward, M Ogborne, A Goldin, D J Birkett.   

Abstract

The influence of liver volume and body weight on plasma theophylline clearance was investigated in asthmatic children and adults. A linear relationship (r = +0.99) was demonstrated between ideal body weight and liver volume estimated by an ultrasonic scanning technique. Age-related changes in liver volume-to-body weight ratio could account for only 30% of differences in plasma theophylline clearance (1/h/kg) between children and adults. It is summized that increased hepatic mixed function oxidase activity is the major contributor to the higher plasma theophylline clearance in children.

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Year:  1983        PMID： 6861869     DOI： 10.1007/bf00609898

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  13 in total

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7.  Comparison of the hydroxylation of zoxazolamine and benzo[a]pyrene in human placenta: effect of cigarette smoking.

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Journal:  Clin Pharmacol Ther       Date:  1976-11       Impact factor: 6.875

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Authors:  J J Grygiel; D J Birkett
Journal:  Clin Pharmacol Ther       Date:  1980-10       Impact factor: 6.875

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  4 in total

1.  Relationship of bioelectrical impedance to pharmacokinetic parameters of theophylline in healthy males.

Authors:  B J Zarowitz; E Peterson; J Popovich
Journal:  Clin Pharmacokinet       Date:  1989-09       Impact factor: 6.447

Review 2.  Influence of endogenous and exogenous effectors on the pharmacokinetics of theophylline. Focus on biotransformation.

Authors:  U Tröger; F P Meyer
Journal:  Clin Pharmacokinet       Date:  1995-04       Impact factor: 6.447

3.  Cimetidine pharmacokinetics and dosage requirements in children.

Authors:  A Somogyi; M Becker; R Gugler
Journal:  Eur J Pediatr       Date:  1985-05       Impact factor: 3.183

Review 4.  Lean body mass as a predictor of drug dosage. Implications for drug therapy.

Authors:  D J Morgan; K M Bray
Journal:  Clin Pharmacokinet       Date:  1994-04       Impact factor: 6.447
  4 in total

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