Literature DB >> 6860343

Presence of low molecular weight polypeptides in human brunescent cataracts.

J Horwitz, J S Hansen, C C Cheung, L L Ding, B R Straatsma, D O Lightfoot, L J Takemoto.   

Abstract

Microdissected sections from opaque & brunescent lens nuclei contain low molecular weight (4,000-8,000 dalton) polypeptides not found in microdissected sections of transparent lens nuclei. Tryptic digestion of these polypeptides from different cataracts reveal similar peptide maps. Together, these results support the involvement of proteolysis in human cataractogenesis, and suggest the possibility of similar molecular mechanisms occurring in cleavage of lens polypeptides during formation of the opaque & brunescent human cataract.

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Year:  1983        PMID： 6860343     DOI： 10.1016/0006-291x(83)90432-1

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Relationship between proteins encoded by three human gamma-crystallin genes and distinct polypeptides in the eye lens.

Authors:  P Russell; S O Meakin; T C Hohman; L C Tsui; M L Breitman
Journal:  Mol Cell Biol       Date:  1987-09       Impact factor: 4.272

2.  Differential inhibition of two proteolytic activities in bovine lens neutral-proteinase preparations.

Authors:  B J Wagner; J W Margolis; A S Abramovitz; S C Fu
Journal:  Biochem J       Date:  1985-06-01       Impact factor: 3.857

3.  The critical role of the central hydrophobic core (residues 71-77) of amyloid-forming αA66-80 peptide in α-crystallin aggregation: a systematic proline replacement study.

Authors:  Rama Kannan; Murugesan Raju; Krishna K Sharma
Journal:  Amyloid       Date:  2014-02-19       Impact factor: 7.141

4.  RETRACTED: Peptide-induced formation of protein aggregates and amyloid fibrils in human and guinea pig αA-crystallins under physiological conditions of temperature and pH.

Authors:  Anbarasu Kumarasamy; Sivakumar Jeyarajan; Jonathan Cheon; Anthony Premceski; Eric Seidel; Victoria A Kimler; Frank J Giblin
Journal:  Exp Eye Res       Date:  2018-11-15       Impact factor: 3.467

5.  Significance of interactions of low molecular weight crystallin fragments in lens aging and cataract formation.

Authors:  Puttur Santhoshkumar; Padmanabha Udupa; Raju Murugesan; K Krishna Sharma
Journal:  J Biol Chem       Date:  2008-01-28       Impact factor: 5.157

Review 6.  Lens aging: effects of crystallins.

Authors:  K Krishna Sharma; Puttur Santhoshkumar
Journal:  Biochim Biophys Acta       Date:  2009-05-20

7.  Anti-chaperone betaA3/A1(102-117) peptide interacting sites in human alphaB-crystallin.

Authors:  Guruprasad Rao; Puttur Santhoshkumar; K Krishna Sharma
Journal:  Mol Vis       Date:  2008-03-26       Impact factor: 2.367
  7 in total

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