Literature DB >> 6860306

Abnormal phosphocreatine metabolism in perfused diabetic hearts. A 31P nuclear-magnetic-resonance study.

G M Pieper, J M Salhany, W J Murray, S T Wu, R S Eliot.   

Abstract

31P n.m.r. analysis of control and diabetic hearts perfused for 1 h with a glucose buffer showed constant and normal levels of phosphocreatine and ATP. Supplementing the buffer with 0.5, 1.2 or 2.0 mM-palmitic acid had little or no effect on high-energy-phosphate levels in control hearts. In contrast, increases in palmitate concentration produced significant decreases in ATP in diabetic hearts, despite normal and constant levels of phosphocreatine. This 31P n.m.r. study suggests a defect in phosphocreatine metabolism in the perfused diabetic heart that might be related to creatine kinase kinetics.

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Year:  1983        PMID： 6860306      PMCID： PMC1154247          DOI： 10.1042/bj2100477

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

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Authors:  M Klingenberg; K Grebe; B Scherer
Journal:  Eur J Biochem       Date:  1975-03-17

2.  Reduced high-energy phosphate levels in rat hearts. I. Effects of alloxan diabetes.

Authors:  T B Allison; S P Bruttig; M F Crass; R S Eliot; J C Shipp
Journal:  Am J Physiol       Date:  1976-06

3.  Effects of high-energy phosphate depletion and repletion on the dynamics and electrocardiogram of isolated rat hearts.

Authors:  J Scheuer; S W Stezoski
Journal:  Circ Res       Date:  1968-10       Impact factor: 17.367

4.  Effect of pressure development on glucose and palmitate metabolism in perfused heart.

Authors:  M F Crass; E S McCaskill; J C Shipp
Journal:  Am J Physiol       Date:  1969-06

5.  Effect of insulin treatment in vivo on heart glycerides and glycogen of alloxan-diabetic rats.

Authors:  R A Rizza; M F Crass; J C Shipp
Journal:  Metabolism       Date:  1971-06       Impact factor: 8.694

6.  Effect of organic and inorganic phosphates on the oxygen equilibrium of human erythrocytes.

Authors:  A Chanutin; R R Curnish
Journal:  Arch Biochem Biophys       Date:  1967-07       Impact factor: 4.013

7.  The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin.

Authors:  R Benesch; R E Benesch
Journal:  Biochem Biophys Res Commun       Date:  1967-01-23       Impact factor: 3.575

8.  Acyl-CoA inhibition of adenine nucleotide translocation in ischemic myocardium.

Authors:  A L Shug; E Shrago; N Bittar; J D Folts; J R Koke
Journal:  Am J Physiol       Date:  1975-03

9.  Effects of increased heart work on glycolysis and adenine nucleotides in the perfused heart of normal and diabetic rats.

Authors:  L H Opie; K R Mansford; P Owen
Journal:  Biochem J       Date:  1971-09       Impact factor: 3.857

10.  Accumulation of myocardial triglycerides ketotic diabetes; evidence for increased biosynthesis.

Authors:  V K Murthy; J C Shipp
Journal:  Diabetes       Date:  1977-03       Impact factor: 9.461
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  3 in total

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Authors:  Julian L Griffin; Helen Atherton; John Shockcor; Luigi Atzori
Journal:  Nat Rev Cardiol       Date:  2011-09-20       Impact factor: 32.419

2.  Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy.

Authors:  H Löster; T Keller; J Grommisch; W Gründer
Journal:  Mol Cell Biochem       Date:  1999-10       Impact factor: 3.396

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Authors:  D Lagadic-Gossmann; J M Chesnais; D Feuvray
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  3 in total

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