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Literature DB >> 6860305

Nucleoside transport in human erythrocytes. A simple carrier with directional symmetry in fresh cells, but with directional asymmetry in cells from outdated blood.

S M Jarvis, J R Hammond, A R Paterson, A S Clanachan.

Abstract

Kinetic characteristics of the transport of uridine, a non-metabolized permeant in human erythrocytes, have been compared in erythrocytes from fresh and outdated stored blood. Uridine transport kinetics in fresh cells conformed to the predictions of a simple carrier model operating with directional symmetry, but in erythrocytes from outdated blood the kinetic characteristics of uridine transport were those of an asymmetric system. The latter result agrees with earlier reports by others. The mobility of the loaded and empty carriers differed by about 6- and 12-fold in fresh and outdated blood, respectively.

Entities: Chemical Species

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Year: 1983 PMID： 6860305 PMCID： PMC1154244 DOI： 10.1042/bj2100457

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

14 in total

1. Testing and characterizing the simple carrier.

Authors: W R Lieb; W D Stein
Journal: Biochim Biophys Acta Date: 1974-12-10

2. Use of 4-nitrobenzylthioinosine in the measurement of rates of nucleoside transport in human erythrocytes.

Authors: M A Pickard; A R Paterson
Journal: Can J Biochem Date: 1972-07

3. Nucleoside transport. I. A mediated process in human erythrocytes.

Authors: J M Oliver; A R Paterson
Journal: Can J Biochem Date: 1971-02

4. Transport of uridine in human red blood cells. Demonstration of a simple carrier-mediated process.

Authors: Z I Cabantchik; H Ginsburg
Journal: J Gen Physiol Date: 1977-01 Impact factor: 4.086

Review 5. Transport of nucleoside drugs in animal cells.

Authors: A R Paterson; N Kolassa; C E Cass
Journal: Pharmacol Ther Date: 1981 Impact factor: 12.310

6. Nucleoside transport in human and sheep erythrocytes. Evidence that nitrobenzylthioinosine binds specifically to functional nucleoside-transport sites.

Authors: S M Jarvis; J D Young
Journal: Biochem J Date: 1980-08-15 Impact factor: 3.857

7. Nucleoside transport in sheep erythrocytes: genetically controlled transport variation and its influence on erythrocyte ATP concentrations.

Authors: J D Young
Journal: J Physiol Date: 1978-04 Impact factor: 5.182

8. Is inosine the physiological energy source of pig erythrocytes?

Authors: S M Jarvis; J D Young; M Ansay; A L Archibald; R A Harkness; R J Simmonds
Journal: Biochim Biophys Acta Date: 1980-03-27

9. Thymidine transport in cultured mammalian cells. Kinetic analysis, temperature dependence and specificity of the transport system.

Authors: R M Wohlhueter; R Marz; P G Plagemann
Journal: Biochim Biophys Acta Date: 1979-05-17

10. Absence of binding sites for the transport inhibitor nitrobenzylthioinosine on nucleoside transport-deficient mouse lymphoma cells.

Authors: C E Cass; N Kolassa; Y Uehara; E Dahlig-Harley; E R Harley; A R Paterson
Journal: Biochim Biophys Acta Date: 1981-12-21

11 in total

1. A combined specific target site binding and pharmacokinetic model to explore the non-linear disposition of draflazine.

Authors: E Snoeck; P Jacqmin; A Van Peer; M Danhof
Journal: J Pharmacokinet Biopharm Date: 1999-06

Review 2. Expression of substrate specificity in facilitated transport systems.

Authors: R M Krupka
Journal: J Membr Biol Date: 1990-07 Impact factor: 1.843

3. Saturable and non-saturable components of choline transport in Plasmodium-infected mammalian erythrocytes: possible role of experimental conditions.

Authors: M L Ancelin; H J Vial
Journal: Biochem J Date: 1992-04-15 Impact factor: 3.857

Nucleoside transport in human erythrocytes. A simple carrier with directional symmetry in fresh cells, but with directional asymmetry in cells from outdated blood.

1. Testing and characterizing the simple carrier.

2. Use of 4-nitrobenzylthioinosine in the measurement of rates of nucleoside transport in human erythrocytes.

3. Nucleoside transport. I. A mediated process in human erythrocytes.

4. Transport of uridine in human red blood cells. Demonstration of a simple carrier-mediated process.

Review 5. Transport of nucleoside drugs in animal cells.

6. Nucleoside transport in human and sheep erythrocytes. Evidence that nitrobenzylthioinosine binds specifically to functional nucleoside-transport sites.

7. Nucleoside transport in sheep erythrocytes: genetically controlled transport variation and its influence on erythrocyte ATP concentrations.

8. Is inosine the physiological energy source of pig erythrocytes?

9. Thymidine transport in cultured mammalian cells. Kinetic analysis, temperature dependence and specificity of the transport system.

10. Absence of binding sites for the transport inhibitor nitrobenzylthioinosine on nucleoside transport-deficient mouse lymphoma cells.

1. A combined specific target site binding and pharmacokinetic model to explore the non-linear disposition of draflazine.

Review 2. Expression of substrate specificity in facilitated transport systems.

3. Saturable and non-saturable components of choline transport in Plasmodium-infected mammalian erythrocytes: possible role of experimental conditions.

4. Alternating carrier models of asymmetric glucose transport violate the energy conservation laws.

5. Reassessment of models of facilitated transport and cotransport.

6. Inhibition by nucleosides of glucose-transport activity in human erythrocytes.

7. Na+-coupled glycine transport in reticulocyte vesicles of distinct sidedness: stoichiometry and symmetry.

8. Kinetics of nitrobenzylthioinosine binding to the human erythrocyte nucleoside transporter.

9. Interaction of [3H]dipyridamole with the nucleoside transporters of human erythrocytes and cultured animal cells.

10. Trans-stimulation and trans-inhibition of uridine efflux from human erythrocytes by permeant nucleosides.