| Literature DB >> 6850867 |
Abstract
We report here that skin fibroblasts from individuals with hereditary adenomatosis of the colon and rectum (ACR), an autosomal dominant trait, were not abnormally sensitive to x-rays, UV-light or MNNG. ACR cells were also competent in restoring x-rays and UV-light induced damage of SV40 T-antigen expression following infection of these cells by the irradiated virus. We concluded, therefore, that sensitivity to x-rays, UV-light and MNNG can not be used to identify gene-carriers dominantly predisposed to colon cancer.Entities:
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Year: 1983 PMID： 6850867 DOI： 10.1016/0309-1651(83)90077-2
Source DB: PubMed Journal: Cell Biol Int Rep ISSN： 0309-1651