Literature DB >> 2838489

Comparison of radiation-induced chromosomal damage between normal individuals and patients with familial polyposis coli.

S Kakati1, L Herrera, R E Drury, A A Sandberg.   

Abstract

Cultured leukocytes of peripheral blood obtained from normal, healthy individuals and from patients with familial polyposis coli (FP) were exposed to 0 rads or 300 rads of 137Cs gamma radiation at G0 to compare damage in these two groups. Only cells in the first mitotic division were considered. The average chromosomal damage in the FP patients was not significantly higher than that in the normal group. The induced chromosomal damage at G0 was normally distributed in both the control and the patient groups as well as when they were combined.

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Year:  1988        PMID： 2838489     DOI： 10.1007/BF00405837

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  21 in total

1.  Chromosome instability in patients with medullary carcinoma of the thyroid.

Authors:  T C Hsu; S Pathak; N Samaan; R C Hickey
Journal:  JAMA       Date:  1981-11-06       Impact factor: 56.272

2.  Failure to demonstrate a chromosome 2 deletion in adenomatous colorectal polyposis patients.

Authors:  R M Fineman; M Morgan; R W Burt; E J Gardner
Journal:  Cancer       Date:  1984-01-15       Impact factor: 6.860

3.  Localization of the gene for familial adenomatous polyposis on chromosome 5.

Authors:  W F Bodmer; C J Bailey; J Bodmer; H J Bussey; A Ellis; P Gorman; F C Lucibello; V A Murday; S H Rider; P Scambler
Journal:  Nature       Date:  1987 Aug 13-19       Impact factor: 49.962

4.  Growth abnormalities of cultured human skin fibroblasts derived from individuals with hereditary adenomatosis of the colon and rectum.

Authors:  L Pfeffer; M Lipkin; O Stutman; L Kopelovich
Journal:  J Cell Physiol       Date:  1976-09       Impact factor: 6.384

Review 5.  Hereditary adenomatosis of the colon and rectum: relevance to cancer promotion and cancer control in humans.

Authors:  L Kopelovich
Journal:  Cancer Genet Cytogenet       Date:  1982-04

6.  Gardner syndrome in a man with an interstitial deletion of 5q.

Authors:  L Herrera; S Kakati; L Gibas; E Pietrzak; A A Sandberg
Journal:  Am J Med Genet       Date:  1986-11

7.  Skin fibroblasts from humans predisposed to colon cancer are not abnormally sensitive to DNA damaging agents.

Authors:  L Kopelovich
Journal:  Cell Biol Int Rep       Date:  1983-05

8.  Elevated levels of p53 antigen in cultured skin fibroblasts from patients with hereditary adenocarcinoma of the colon and rectum and its relevance to oncogenic mechanisms.

Authors:  L Kopelovich; A B DeLeo
Journal:  J Natl Cancer Inst       Date:  1986-12       Impact factor: 13.506

9.  Familial polyposis coli: growth characteristics of karyotypically variable cultured fibroblasts, response to epidermal growth factor and the tumour promoter 12-0-tetradecanoyl phorbol-13-acetate.

Authors:  S H Rider; H A Mazzullo; M B Davis; J D Delhanty
Journal:  J Med Genet       Date:  1986-04       Impact factor: 6.318

10.  Correlation between O6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N'-nitro-N-nitrosoguanidine.

Authors:  J Domoradzki; A E Pegg; M E Dolan; V M Maher; J J McCormick
Journal:  Carcinogenesis       Date:  1984-12       Impact factor: 4.944
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