Literature DB >> 684435

Secretion in mast cells induced by calcium entrapped within phospholipid vesicles.

T C Theoharides, W W Douglas.   

Abstract

Purified mast cells secreted histamine when fused to phospholipid vesicles containing calcium but not magnesium or potassium. Microscopic observation revealed highly localized exocytotic responses involving punctate extrusion of individual granules. Calcium delivered from the vesicles to the cytoplasm is apparently a sufficient stimulus to initiate exocytosis. The results support the calcium hypothesis of stimulus-secretion coupling.

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Year:  1978        PMID： 684435     DOI： 10.1126/science.684435

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

Review 1.  Mast cells and inflammation.

Authors:  Theoharis C Theoharides; Konstantinos-Dionysios Alysandratos; Asimenia Angelidou; Danae-Anastasia Delivanis; Nikolaos Sismanopoulos; Bodi Zhang; Shahrzad Asadi; Magdalini Vasiadi; Zuyi Weng; Alexandra Miniati; Dimitrios Kalogeromitros
Journal:  Biochim Biophys Acta       Date:  2010-12-23

Review 2.  Calcium and mast cell activation.

Authors:  F L Pearce
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335

3.  On the calcium receptor activating exocytosis: inhibitory effects of calmodulin-interacting drugs on rat mast cells.

Authors:  W W Douglas; E F Nemeth
Journal:  J Physiol       Date:  1982-02       Impact factor: 5.182

4.  Histamine secretion: research in retrospect.

Authors:  B Diamant
Journal:  Agents Actions       Date:  1982-04

5.  Uptake of liposomes containing the photoprotein obelin by rat isolated adipocytes. Adhesion, endocytosis or fusion?

Authors:  M B Hallett; A K Campbell
Journal:  Biochem J       Date:  1980-11-15       Impact factor: 3.857

6.  Effect of interleukin-1 receptor antagonist (IL-1RA) on histamine and serotonin release by rat basophilic leukemia cells (RBL-2H3) and peritoneal mast cells.

Authors:  P Conti; W Bouchet; C Feliciani; S Mammarella; L Kudchadker; R C Barbacane; M Reale; I Haggag; G Bruneau; J Thibault; T C Theoharides
Journal:  Mol Cell Biochem       Date:  1996-02-09       Impact factor: 3.396

7.  The role of cyclic AMP and its protein kinase in mediating acetylcholine release and the action of adenosine at frog motor nerve endings.

Authors:  J K Hirsh; E M Silinsky; C S Solsona
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

8.  Intracellular magnesium does not antagonize calcium-dependent acetylcholine secretion.

Authors:  E D Kharasch; A M Mellow; E M Silinsky
Journal:  J Physiol       Date:  1981-05       Impact factor: 5.182

9.  Neurotransmitter release evoked by nerve impulses without Ca2+ entry through Ca2+ channels in frog motor nerve endings.

Authors:  E M Silinsky; M Watanabe; R S Redman; R Qiu; J K Hirsh; J M Hunt; C S Solsona; S Alford; R C MacDonald
Journal:  J Physiol       Date:  1995-02-01       Impact factor: 5.182

Review 10.  Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin.

Authors:  Theoharis C Theoharides; Julia M Stewart; Erifili Hatziagelaki; Gerasimos Kolaitis
Journal:  Front Neurosci       Date:  2015-07-03       Impact factor: 4.677
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