Literature DB >> 6839186

Failure of thymic grafts to stimulate resorption of bone in the Fatty/Orl-op rat.

N W Nisbet, S F Waldron, M J Marshall.   

Abstract

An infusion of compatible normal bone marrow stimulated bone resorption in both unthymectomized and thymectomized Fatty/Orl-op osteopetrotic rats. Bone resorption was not stimulated by compatible normal thymic grafts in either unthymectomized or thymectomized mutants. It is concluded that the thymus is not fundamental in the cure of osteopetrosis in this strain of osteopetrotic rat and that the defect lies in myeloid rather than thymic regulation of osteoclastic function.

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Year:  1983        PMID： 6839186     DOI： 10.1007/bf02405017

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  15 in total

1.  Studies of the cellular cure for osteopetrosis by transplanted cells: specificity of the cell type in ia rats.

Authors:  S C Marks
Journal:  Am J Anat       Date:  1978-01

2.  Genetic study of osteopetrosis in the Norway rat.

Authors:  R Moutier; K Toyama; M F Charrier
Journal:  J Hered       Date:  1974 Nov-Dec       Impact factor: 2.645

3.  Role of osteoblasts in hormonal control of bone resorption--a hypothesis.

Authors:  G A Rodan; T J Martin
Journal:  Calcif Tissue Int       Date:  1981       Impact factor: 4.333

4.  Phagocytic recognition of bone by macrophages.

Authors:  T J Chambers
Journal:  J Pathol       Date:  1981-09       Impact factor: 7.996

Review 5.  The origin of bone cells in the postnatal organism.

Authors:  M Owen
Journal:  Arthritis Rheum       Date:  1980-10

6.  [Cure of osteopetrosis by allogenic bone marrow injection in the double mutant "osteopetrosi-athymic" rat].

Authors:  R Moutier; K Toyama; H Lamendin; J J Ballet
Journal:  C R Seances Acad Sci D       Date:  1979-11-19

7.  Bone absorption and the immune system.

Authors:  N W Nisbet
Journal:  Scand J Immunol       Date:  1981-12       Impact factor: 3.487

8.  Osteoclasts derive from hematopoietic stem cells according to marker, giant lysosomes of beige mice.

Authors:  P Ash; J F Loutit; K M Townsend
Journal:  Clin Orthop Relat Res       Date:  1981 Mar-Apr       Impact factor: 4.176

9.  [Curing of the congenital osteopetrosis of "op" rats by thymus grafts].

Authors:  G Milhaud; M L Labat; B Graf; M J Thillard
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1976-09-20

10.  The osteoclast: review of ultrastructure, origin, and structure-function relationship.

Authors:  G Göthlin; J L Ericsson
Journal:  Clin Orthop Relat Res       Date:  1976-10       Impact factor: 4.176
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  4 in total

1.  Bone marrow transplantation in precocious osteopetrosis.

Authors:  N W Nisbet
Journal:  Br Med J (Clin Res Ed)       Date:  1987-02-21

2.  Skeletal resistance to 1,25-dihydroxyvitamin D3 in osteopetrotic rats.

Authors:  F F Safadi; D C Hermey; S N Popoff; M F Seifert
Journal:  Endocrine       Date:  1999-12       Impact factor: 3.633

3.  A secondary immune deficiency in the Fatty/Orl-op rat.

Authors:  S F Evans; N W Nisbet; M J Marshall; D Catty
Journal:  Br J Exp Pathol       Date:  1985-04

4.  Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2.

Authors:  B Perdu; P R Odgren; L Van Wesenbeeck; K Jennes; C C Mackay; W Van Hul
Journal:  Calcif Tissue Int       Date:  2009-03-04       Impact factor: 4.333
  4 in total

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