Literature DB >> 6838601

Determination of active hydrogen content by fast atom bombardment mass spectrometry following hydrogen-deuterium exchange.

S K Sethi, D L Smith, J A McCloskey.   

Abstract

Fast atom bombardment mass spectrometry following hydrogen--deuterium exchange in [hydroxy-2H3]glycerol and 2H20 has been studied as a means of establishing active hydrogen content in molecules of unknown structure. Nucleotides, carbohydrates, one peptide and complex antibiotics, in the mass region to 1500 daltons and 29 exchangeable hydrogens were examined, with a correct hydrogen count unambiguously measured in every case. The method is experimentally simple and applicable on a microgram scale, to salts and a variety of polar compounds of biological origin.

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Year:  1983        PMID： 6838601     DOI： 10.1016/0006-291x(83)91806-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Elucidating the higher-order structure of biopolymers by structural probing and mass spectrometry: MS3D.

Authors:  Daniele Fabris; Eizadora T Yu
Journal:  J Mass Spectrom       Date:  2010-08       Impact factor: 1.982

2.  Observation of zwitterion formation in the gas-phase H/D-exchange with CH(3)OD: solution-phase structures in the gas phase.

Authors:  Nick C Polfer; Robert C Dunbar; Jos Oomens
Journal:  J Am Soc Mass Spectrom       Date:  2006-12-14       Impact factor: 3.109

Review 3.  Analytical Aspects of Hydrogen Exchange Mass Spectrometry.

Authors:  John R Engen; Thomas E Wales
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2015-05-29       Impact factor: 10.745

4.  Adenine photodimerization in deoxyadenylate sequences: elucidation of the mechanism through structural studies of a major d(ApA) photoproduct.

Authors:  S Kumar; P C Joshi; N D Sharma; S N Bose; R Jeremy; H Davies; N Takeda; J A McCloskey
Journal:  Nucleic Acids Res       Date:  1991-06-11       Impact factor: 16.971

5.  Modeling deuterium exchange behavior of ERK2 using pepsin mapping to probe secondary structure.

Authors:  K A Resing; A N Hoofnagle; N G Ahn
Journal:  J Am Soc Mass Spectrom       Date:  1999-08       Impact factor: 3.109

6.  In electrospray ionization source hydrogen/deuterium exchange LC-MS and LC-MS/MS for characterization of metabolites.

Authors:  Wing Lam; Ragu Ramanathan
Journal:  J Am Soc Mass Spectrom       Date:  2002-04       Impact factor: 3.109

7.  Mass spectral characterization of tetracyclines by electrospray ionization, H/D exchange, and multiple stage mass spectrometry.

Authors:  Amin M Kamel; Hassan G Fouda; Phyllis R Brown; Burnaby Munson
Journal:  J Am Soc Mass Spectrom       Date:  2002-05       Impact factor: 3.109

8.  The isolation and characterisation of a new type of dimeric adenine photoproduct in UV-irradiated deoxyadenylates.

Authors:  S Kumar; N D Sharma; R J Davies; D W Phillipson; J A McCloskey
Journal:  Nucleic Acids Res       Date:  1987-02-11       Impact factor: 16.971

9.  Reactive collisions in quadrupole cells. 3: H/D exchange reactions of protonated aromatic amines with ND3.

Authors:  N N Dookeran; A G Harrison
Journal:  J Am Soc Mass Spectrom       Date:  1995-01       Impact factor: 3.109

10.  Gas phase hydrogen / deuterium exchange in electrospray ionization mass spectrometry as a practical tool for structure elucidation.

Authors:  M E Hemling; J J Conboy; M F Bean; M Mentzer; S A Carr
Journal:  J Am Soc Mass Spectrom       Date:  1994-05       Impact factor: 3.109
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