Literature DB >> 6836308

Formation of an adenine-thymine photoadduct in the deoxydinucleoside monophosphate d(TpA) and in DNA.

S N Bose, R J Davies, S K Sethi, J A McCloskey.   

Abstract

A photoadduct is formed between the adenine (A) and thymine (T) bases of the deoxydinucleoside monophosphate d(TpA) when it is irradiated at 254 nanometers in aqueous solution. Treatment of the photoadduct with acid converts it specifically into a fluorescent hydrolysis product, C7H7N3O, incorporating the position-8 carbon of adenine and the methyl group of thymine. Isolation of the fluorescent hydrolysis product from acid hydrolyzates of oligo- and polydeoxyribonucleotides has shown that the photoadduct is formed by ultraviolet irradiation of d(pTpA), d(TpApT), d(TpApTpA), poly(dA-dT), and both single- and double-stranded DNA.

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Year:  1983        PMID： 6836308     DOI： 10.1126/science.6836308

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  24 in total

1.  Mutagenicity of a unique thymine-thymine dimer or thymine-thymine pyrimidine pyrimidone (6-4) photoproduct in mammalian cells.

Authors:  A Gentil; F Le Page; A Margot; C W Lawrence; A Borden; A Sarasin
Journal:  Nucleic Acids Res       Date:  1996-05-15       Impact factor: 16.971

2.  DNA sequence context affects UV-induced mutagenesis in Escherichia coli.

Authors:  Wai Bing Mak; Douglas Fix
Journal:  Mutat Res       Date:  2007-10-13       Impact factor: 2.433

3.  Photocrosslinking of human telomeric G-quadruplex loops by anti cyclobutane thymine dimer formation.

Authors:  Dian G T Su; Huafeng Fang; Michael L Gross; John-Stephen A Taylor
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-23       Impact factor: 11.205

Review 4.  Mechanisms of DNA damage, repair, and mutagenesis.

Authors:  Nimrat Chatterjee; Graham C Walker
Journal:  Environ Mol Mutagen       Date:  2017-05-09       Impact factor: 3.216

5.  Sequence effect on alkali-sensitive sites in UV-irradiated SV40 DNA.

Authors:  F Bourre; G Renault; A Sarasin
Journal:  Nucleic Acids Res       Date:  1987-11-11       Impact factor: 16.971

6.  Photoswitchable formation of a DNA interstrand cross-link by a coumarin-modified nucleotide.

Authors:  Mohammad Mojibul Haque; Huabing Sun; Shuo Liu; Yinsheng Wang; Xiaohua Peng
Journal:  Angew Chem Int Ed Engl       Date:  2014-05-19       Impact factor: 15.336

7.  Detection of UV purine photoproducts in a defined sequence of human DNA.

Authors:  P E Gallagher; N J Duker
Journal:  Mol Cell Biol       Date:  1986-02       Impact factor: 4.272

8.  Mutation spectra of TA*, the major photoproduct of thymidylyl-(3'5')-deoxyadenosine, in Escherichia coli under SOS conditions.

Authors:  X Zhao; J S Taylor
Journal:  Nucleic Acids Res       Date:  1996-04-15       Impact factor: 16.971

9.  The structure of d(TpA), the major photoproduct of thymidylyl-(3'5')-deoxyadenosine.

Authors:  X Zhao; S Nadji; J L Kao; J S Taylor
Journal:  Nucleic Acids Res       Date:  1996-04-15       Impact factor: 16.971

10.  Binding of transcription factors creates hot spots for UV photoproducts in vivo.

Authors:  G P Pfeifer; R Drouin; A D Riggs; G P Holmquist
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272
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