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Literature DB >> 3785156

Detection of UV purine photoproducts in a defined sequence of human DNA.

Abstract

The UV-irradiated, 3'-end-labeled, 92-base-pair terminus of the human alphoid sequence was incubated with purified endonuclease v. Previously unreported photoproducts were incised at purine loci. These were not pyrimidine photodimers, 6-4'-(pyrimidin-2'-one)-pyrimidines, base loss sites, or ring-opened purines. Therefore, purine-containing photoproducts, possibly dimers, were incised by the enzyme preparation.

Entities: Chemical Gene Species

Mesh：

Substances：
Purines
DNA

Year: 1986 PMID： 3785156 PMCID： PMC367562 DOI： 10.1128/mcb.6.2.707-709.1986

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

19 in total

1. Purification and properties of a pyrimidine dimer-specific endonuclease from E. coli infected with bacteriophage T4.

Authors: E C Friedberg; A K Ganesan; P C Seawell
Journal: Methods Enzymol Date: 1980 Impact factor: 1.600

2. Pyrimidine dimers in UV-irradiated poly dI:dC.

Authors: R B Setlow; W L Carrier; F J Bollum
Journal: Proc Natl Acad Sci U S A Date: 1965-05 Impact factor: 11.205

3. den V gene of bacteriophage T4 determines a DNA glycosylase specific for pyrimidine dimers in DNA.

Authors: P C Seawell; C A Smith; A K Ganesan
Journal: J Virol Date: 1980-09 Impact factor: 5.103

4. Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors: A M Maxam; W Gilbert
Journal: Methods Enzymol Date: 1980 Impact factor: 1.600

5. Inhibition of enzymic incision of thymine dimers by covalently bound 2-[N-[(deoxyguanosin-8-yl)acetyl]amino]fluorene in deoxyribonucleic acid.

Authors: N J Duker; G W Merkel
Journal: Biochemistry Date: 1985-01-15 Impact factor: 3.162

6. Apurinic/apyrimidinic endonucleases in repair of pyrimidine dimers and other lesions in DNA.

Authors: H R Warner; B F Demple; W A Deutsch; C M Kane; S Linn
Journal: Proc Natl Acad Sci U S A Date: 1980-08 Impact factor: 11.205

7. Comparison of the cleavage of pyrimidine dimers by the bacteriophage T4 and Micrococcus luteus UV-specific endonucleases.

Authors: L K Gordon; W A Haseltine
Journal: J Biol Chem Date: 1980-12-25 Impact factor: 5.157

8. DNA N-glycosylases and UV repair.

Authors: B Demple; S Linn
Journal: Nature Date: 1980-09-18 Impact factor: 49.962

9. A pyrimidine dimer-DNA glycosylase activity associated with the v gene product of bacterophage T4.

Authors: E H Radany; E C Friedberg
Journal: Nature Date: 1980-07-10 Impact factor: 49.962

10. Evidence that pyrimidine dimers in DNA can give rise to tumors.

Authors: R W Hart; R B Setlow; A D Woodhead
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

15 in total

1. Mutagenicity of a unique thymine-thymine dimer or thymine-thymine pyrimidine pyrimidone (6-4) photoproduct in mammalian cells.

Authors: A Gentil; F Le Page; A Margot; C W Lawrence; A Borden; A Sarasin
Journal: Nucleic Acids Res Date: 1996-05-15 Impact factor: 16.971

Detection of UV purine photoproducts in a defined sequence of human DNA.

1. Purification and properties of a pyrimidine dimer-specific endonuclease from E. coli infected with bacteriophage T4.

2. Pyrimidine dimers in UV-irradiated poly dI:dC.

3. den V gene of bacteriophage T4 determines a DNA glycosylase specific for pyrimidine dimers in DNA.

4. Sequencing end-labeled DNA with base-specific chemical cleavages.

5. Inhibition of enzymic incision of thymine dimers by covalently bound 2-[N-[(deoxyguanosin-8-yl)acetyl]amino]fluorene in deoxyribonucleic acid.

6. Apurinic/apyrimidinic endonucleases in repair of pyrimidine dimers and other lesions in DNA.

7. Comparison of the cleavage of pyrimidine dimers by the bacteriophage T4 and Micrococcus luteus UV-specific endonucleases.

8. DNA N-glycosylases and UV repair.

9. A pyrimidine dimer-DNA glycosylase activity associated with the v gene product of bacterophage T4.

10. Evidence that pyrimidine dimers in DNA can give rise to tumors.

1. Mutagenicity of a unique thymine-thymine dimer or thymine-thymine pyrimidine pyrimidone (6-4) photoproduct in mammalian cells.

2. Sequence effect on alkali-sensitive sites in UV-irradiated SV40 DNA.

3. A novel photoproduct of 2'-deoxyguanosine induced by acetone photosensitization: 8-(2,3,4-trihydroxybutyl)guanine.

4. Photoalkylated DNA and ultraviolet-irradiated DNA are incised at cytosines by endonuclease III.

5. Binding of transcription factors creates hot spots for UV photoproducts in vivo.

6. UV-induced photoproducts of 5-methylcytosine in a DNA sequence context.

7. Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells.

8. HPLC photofingerprinting of conformational peculiarities and transitions in oligonucleotide duplexes.

9. Excision of cytosine hydrates from Z-DNA.

10. The specificity of UV-induced mutations at an endogenous locus in mammalian cells.