Literature DB >> 6835382

Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen.

G L Smith, M Mackett, B Moss.   

Abstract

Potential live vaccines against hepatitis B virus have been produced. The coding sequence for hepatitis B virus surface antigen (HBsAg) has been inserted into the vaccinia virus genome under control of vaccinia virus early promoters. Cells infected with these vaccinia virus recombinants synthesize and excrete HBsAg and vaccinated rabbits rapidly produce antibodies to HBsAg.

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Year:  1983        PMID： 6835382     DOI： 10.1038/302490a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  129 in total

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