Literature DB >> 6834387

Synthesis and antineoplastic activity of 3'-azido and 3'-amino analogues of pyrimidine deoxyribonucleoside.

T S Lin, W R Mancini.   

Abstract

Several new 3'-azido and 3'-amino nucleosides (8, 9, 12, and 13) have been synthesized and their biological activities evaluated. Among them, 3'-amino-2',3'-dideoxycytidine (13) was found to exhibit potent cytotoxic activity against both L1210 and S-180 cells in vitro with an ID50 of 0.7 and 4.0 microM, respectively. Furthermore, 13 has also shown antitumor activity against L1210 tumor bearing mice with a T/C X 100 value of 283.

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Year:  1983        PMID： 6834387     DOI： 10.1021/jm00358a016

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  Nucleotide Analogues as Probes for DNA and RNA Polymerases.

Authors:  Robert D Kuchta
Journal:  Curr Protoc Chem Biol       Date:  2010

2.  Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products.

Authors:  Hari K Akula; Hariprasad Kokatla; Graciela Andrei; Robert Snoeck; Dominique Schols; Jan Balzarini; Lijia Yang; Mahesh K Lakshman
Journal:  Org Biomol Chem       Date:  2017-02-01       Impact factor: 3.876

3.  Efficient methods for attachment of thiol specific probes to the 3'-ends of synthetic oligodeoxyribonucleotides.

Authors:  R Zuckermann; D Corey; P Schultz
Journal:  Nucleic Acids Res       Date:  1987-07-10       Impact factor: 16.971

4.  The role of deoxycytidine-metabolizing enzymes in the cytotoxicity induced by 3'-amino-2',3'-dideoxycytidine and cytosine arabinoside.

Authors:  W R Mancini
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333
  4 in total

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