Literature DB >> 6833125

Thiotetromycin, a new antibiotic. Taxonomy, production, isolation, and physicochemical and biological properties.

S Omura, Y Iwai, A Nakagawa, R Iwata, Y Takahashi, H Shimizu, H Tanaka.   

Abstract

A new antibiotic, thiotetromycin, has been isolated from the culture filtrate of Streptomyces sp. OM-674 by solvent extraction and silica gel chromatography. The molecular formula of the antibiotic has been determined as C13H18O2S on the basis of elemental analysis and its high resolution mass spectrometry. The antibiotic contains a thiotetronic acid in the molecule and possesses a selective activity against Bacteroides fragilis.

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Year:  1983        PMID： 6833125     DOI： 10.7164/antibiotics.36.109

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

1.  Discovery of FabH/FabF inhibitors from natural products.

Authors:  Katherine Young; Hiranthi Jayasuriya; John G Ondeyka; Kithsiri Herath; Chaowei Zhang; Srinivas Kodali; Andrew Galgoci; Ronald Painter; Vickie Brown-Driver; Robert Yamamoto; Lynn L Silver; Yingcong Zheng; Judith I Ventura; Janet Sigmund; Sookhee Ha; Angela Basilio; Francisca Vicente; José Rubén Tormo; Fernando Pelaez; Phil Youngman; Doris Cully; John F Barrett; Dennis Schmatz; Sheo B Singh; Jun Wang
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

2.  Structure of 3-oxoacyl-(acyl-carrier protein) synthase II from Thermus thermophilus HB8.

Authors:  Bagautdin Bagautdinov; Yoko Ukita; Masashi Miyano; Naoki Kunishima
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-04-30

3.  Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method.

Authors:  Hiroaki Gouda; Toshiaki Sunazuka; Hideaki Ui; Masaki Handa; Yusuke Sakoh; Yuzuru Iwai; Shuichi Hirono; Satoshi Omura
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-12       Impact factor: 11.205

Review 4.  Philosophy of new drug discovery.

Authors:  S Omura
Journal:  Microbiol Rev       Date:  1986-09

5.  Novel route to 5-position vinyl derivatives of thiolactomycin: Olefination vs. deformylation.

Authors:  Pilho Kim; Clifton E Barry; Cynthia S Dowd
Journal:  Tetrahedron Lett       Date:  2006-05-15       Impact factor: 2.415

6.  Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives.

Authors:  Marlene L Rothe; Jie Li; Ernesto Garibay; Bradley S Moore; Shaun M K McKinnie
Journal:  Org Biomol Chem       Date:  2019-03-27       Impact factor: 3.876

7.  Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

Authors:  Jun Wang; Srinivas Kodali; Sang Ho Lee; Andrew Galgoci; Ronald Painter; Karen Dorso; Fred Racine; Mary Motyl; Lorraine Hernandez; Elizabeth Tinney; Steven L Colletti; Kithsiri Herath; Richard Cummings; Oscar Salazar; Ignacio González; Angela Basilio; Francisca Vicente; Olga Genilloud; Fernando Pelaez; Hiranthi Jayasuriya; Katherine Young; Doris F Cully; Sheo B Singh
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-24       Impact factor: 11.205

8.  A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis.

Authors:  W Tao; M E Yurkovich; S Wen; K E Lebe; M Samborskyy; Y Liu; A Yang; Y Liu; Y Ju; Z Deng; M Tosin; Y Sun; P F Leadlay
Journal:  Chem Sci       Date:  2015-10-08       Impact factor: 9.825
  8 in total

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