Literature DB >> 6832291

Effects of cysteine and N-acetyl cysteine on GSH content of brain of adult rats.

J Viña, F J Romero, G T Saez, F V Pallardó.   

Abstract

Intraperitoneal injections of cysteine or N-acetyl cysteine induce a depletion of reduced glutathione (GSH) in rat brain. The doses required to promote GSH depletion are lower than those reported to cause a disseminate neurodegenerative syndrome. Since physiological GSH concentrations are required to maintain cell membranes, we suggest that consideration of the cysteine-induced GSH depletion is important in attempts to understand the mechanism of cysteine-induced cytotoxicity in brain.

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Year:  1983        PMID： 6832291     DOI： 10.1007/bf01958877

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.

Authors:  J R Mitchell; S S Thorgeirsson; W Z Potter; D J Jollow; H Keiser
Journal:  Clin Pharmacol Ther       Date:  1974-10       Impact factor: 6.875

2.  Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

Authors:  J R Mitchell; D J Jollow; W Z Potter; J R Gillette; B B Brodie
Journal:  J Pharmacol Exp Ther       Date:  1973-10       Impact factor: 4.030

3.  Cysteine-induced brain damage in infant and fetal rodents.

Authors:  J W Olney; O L Ho; V Rhee; B Schainker
Journal:  Brain Res       Date:  1972-10-13       Impact factor: 3.252

4.  Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine.

Authors:  J W Olney; O L Ho
Journal:  Nature       Date:  1970-08-08       Impact factor: 49.962

5.  Reversal of experimental paracetamol toxicosis with N-acetylcysteine.

Authors:  E Piperno; D A Berssenbruegge
Journal:  Lancet       Date:  1976-10-02       Impact factor: 79.321

6.  Maintenance of glutathione content is isolated hepatocyctes.

Authors:  J Viña; R Hems; H A Krebs
Journal:  Biochem J       Date:  1978-03-15       Impact factor: 3.857

7.  Effect of acetaminophen (paracetamol) and its antagonists on glutathione (GSH) content in rat liver.

Authors:  J Viña; F J Romero; J M Estrela; J R Viña
Journal:  Biochem Pharmacol       Date:  1980-07-01       Impact factor: 5.858
  7 in total
  4 in total

1.  Neuronal growth on L- and D-cysteine self-assembled monolayers reveals neuronal chiral sensitivity.

Authors:  Koby Baranes; Hagay Moshe; Noa Alon; Shmulik Schwartz; Orit Shefi
Journal:  ACS Chem Neurosci       Date:  2014-03-05       Impact factor: 4.418

2.  Oxygen toxicity in the nervous tissue: comparison of the antioxidant defense of rat brain and sciatic nerve.

Authors:  F J Romero; E Monsalve; C Hermenegildo; F J Puertas; V Higueras; E Nies; J Segura-Aguilar; J Romá
Journal:  Neurochem Res       Date:  1991-02       Impact factor: 3.996

3.  Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice.

Authors:  Joanne Clark; Elizabeth L Clore; Kangni Zheng; Anthony Adame; Eliezer Masliah; David K Simon
Journal:  PLoS One       Date:  2010-08-23       Impact factor: 3.240

4.  N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data.

Authors:  Daniel A Monti; George Zabrecky; Daniel Kremens; Tsao-Wei Liang; Nancy A Wintering; Jingli Cai; Xiatao Wei; Anthony J Bazzan; Li Zhong; Brendan Bowen; Charles M Intenzo; Lorraine Iacovitti; Andrew B Newberg
Journal:  PLoS One       Date:  2016-06-16       Impact factor: 3.240
  4 in total

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