Literature DB >> 6832214

Simultaneous absence of the human IgG1, IgG2, IgG4 and IgA1 subclasses: immunological and immunogenetical considerations.

G Lefranc, H Chaabani, E Van Loghem, M P Lefranc, G De Lange, A N Helal.   

Abstract

Simultaneous absence of the IgG1, IgG2, IgG4 and IgA1 immunoglobulins has been unambiguously demonstrated in a healthy 75-year-old woman by testing for allotypes, isoallotypes and for isotypes of these four subclasses. Only IgM, IgD, IgG3, IgA2 and IgE were present. The IgG3 levels were significantly increased. Family investigation showed inheritance of a haplotype Gm-;-;b A2m2. This person is homozygous for an extensive DNA deletion including the C gamma 1, C gamma 2, C gamma 4 and C alpha 1 genes.

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Year:  1983        PMID： 6832214     DOI： 10.1002/eji.1830130312

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  19 in total

1.  Pulsed-field electrophoresis screening for immunoglobulin heavy-chain constant-region (IGHC) multigene deletions and duplications.

Authors:  A Bottaro; U Cariota; M DeMarchi; A O Carbonara
Journal:  Am J Hum Genet       Date:  1991-04       Impact factor: 11.025

Review 2.  Human immunoglobulin allotypes: possible implications for immunogenicity.

Authors:  Roy Jefferis; Marie-Paule Lefranc
Journal:  MAbs       Date:  2009 Jul-Aug       Impact factor: 5.857

3.  Salivary IgG subclasses in individuals with and without homozygous IGHG gene deletions.

Authors:  P E Engström; G Norhagen; L Osipova; A Helal; V Wiebe; A Brusco; A O Carbonara; G Lefranc; M P Lefranc
Journal:  Immunology       Date:  1996-10       Impact factor: 7.397

4.  A human immunoglobulin IGHG3 allele (Gmb0,b1,c3,c5,u) with an IGHG4 converted region and three hinge exons.

Authors:  S Huck; G Lefranc; M P Lefranc
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

5.  BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people. Evidence for a major polymorphism.

Authors:  N Ghanem; M Bensmana; J M Dugoujon; J Constans; M P Lefranc; G Lefranc
Journal:  Hum Genet       Date:  1989-08       Impact factor: 4.132

6.  Molecular analysis of the T17 immunoglobulin CH multigene deletion (del A1-GP-G2-G4-E).

Authors:  V Wiebe; A Helal; M P Lefranc; G Lefranc
Journal:  Hum Genet       Date:  1994-05       Impact factor: 4.132

7.  Multiple gene deletions within the human immunoglobulin heavy-chain cluster.

Authors:  N Migone; S Oliviero; G de Lange; D L Delacroix; D Boschis; F Altruda; L Silengo; M DeMarchi; A O Carbonara
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

8.  Selective deficiency of immunoglobulin A2.

Authors:  E van Loghem; B J Zegers; E J Bast; L Kater
Journal:  J Clin Invest       Date:  1983-12       Impact factor: 14.808

9.  Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation.

Authors:  Corey T Watson; Karyn M Steinberg; John Huddleston; Rene L Warren; Maika Malig; Jacqueline Schein; A Jeremy Willsey; Jeffrey B Joy; Jamie K Scott; Tina A Graves; Richard K Wilson; Robert A Holt; Evan E Eichler; Felix Breden
Journal:  Am J Hum Genet       Date:  2013-03-28       Impact factor: 11.025

10.  Novel human immunoglobulin heavy chain constant region gene deletion haplotypes characterized by pulsed-field electrophoresis.

Authors:  P G Olsson; H Rabbani; L Hammarström; C I Smith
Journal:  Clin Exp Immunol       Date:  1993-10       Impact factor: 4.330
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