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Literature DB >> 2570016

BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people. Evidence for a major polymorphism.

N Ghanem¹, M Bensmana, J M Dugoujon, J Constans, M P Lefranc, G Lefranc.

Abstract

In this paper, we extend the study of the IGHG gene RFLPs in black African persons and in some other individuals characterized by a Negroid admixture. We demonstrate a polymorphism that is much more important in black Africans, than in Caucasoids, mainly for the IGHG3 and G1 genes, the most 5' members of the IGHG multigene family. These genes encode for the IgG3 and IgG1 subclasses, which are of crucial biological importance.

Entities: Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2570016 DOI： 10.1007/BF00274144

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

29 in total

1. Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes.

Authors: S Huck; P Fort; D H Crawford; M P Lefranc; G Lefranc
Journal: Nucleic Acids Res Date: 1986-02-25 Impact factor: 16.971

2. Guidelines for human gene nomenclature. An international system for human gene nomenclature (ISGN, 1987).

Authors: T B Shows; P J McAlpine; C Boucheix; F S Collins; P M Conneally; J Frézal; H Gershowitz; P N Goodfellow; J G Hall; P Issitt; C A Jones; B B Knowles; M Lewis; V A McKusick; M Meisler; N E Morton; P Rubenstein; M S Schanfield; R D Schmickel; M H Skolnick; M A Spence; G R Sutherland; M Traver; N Van Cong; H F Willard
Journal: Cytogenet Cell Genet Date: 1987

BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people. Evidence for a major polymorphism.

1. Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes.

2. Guidelines for human gene nomenclature. An international system for human gene nomenclature (ISGN, 1987).

3. Contribution of the GM and INV allotypes to the characterization of human populations.

4. Gm, Am and Km immunoglobulin allotypes of two populations in Tunisia.

5. Unusual heavy chains of human IgG immunoglobulins: rearrangements of the ch domain exons.

6. Analysis of a break in chromosome 14 mapping to the region of the immunoglobulin heavy chain locus.

7. Common and uncommon immunoglobulin haplotypes among Lebanese communities.

8. Human IgG allotypes co-occurring in more than one IgG subclass.

Review 9. Human immunoglobulin heavy-chain multigene deletions in healthy individuals.

10. Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individuals.

1. Molecular characterization of Gm(n+) and G2m(n-) allotypes.

2. A human immunoglobulin IGHG3 allele (Gmb0,b1,c3,c5,u) with an IGHG4 converted region and three hinge exons.

3. Molecular analysis of the T17 immunoglobulin CH multigene deletion (del A1-GP-G2-G4-E).