| Literature DB >> 6828859 |
L M Lichtenberger, L A Graziani, E J Dial, B D Butler, B A Hills.
Abstract
Intragastric administration of a liposomal surfactant suspension markedly reduced acid-induced gastric ulcerogenesis and bleeding in rats. The concentration of surface-active molecules intrinsically present in the gastric mucosa was increased two to six times by administration of 16,16-dimethyl prostaglandin E2. Thus, local accumulation of surface-active phospholipids may be an integral component of the cytoprotective mechanism activated by prostaglandin treatment.Entities:
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Year: 1983 PMID： 6828859 DOI： 10.1126/science.6828859
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728