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Literature DB >> 6828377

Sequence organization in Dictyostelium: unique structure at the 5'-ends of protein coding genes.

Abstract

We have compared the sequences which lie 5' to the coding regions of 15 Dictyostelium genes transcribed by RNA polymerase II. These sequences are extremely (approximately 90%) A + T rich and contain extensive homopolymeric regions. Like most eukaryotic genes, those in Dictyostelium possess a TATA or Goldberg-Hogness Box approximately 25-35bp 5' to the site of transcription initiation. In addition, each gene contains an oligo (dT) stretch between the TATA Box and mRNA start site; this oligo (dT) sequence is, thus far, unique to Dictyostelium. We suggest that the TATA-oligo (dT) structure is an essential component of the Dictyostelium promoter. The general sequence structure of coding, non-coding and untranscribed flanking regions in Dictyostelium is also discussed.

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Year: 1983 PMID： 6828377 PMCID： PMC325732 DOI： 10.1093/nar/11.2.541

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

36 in total

1. Unusual nucleotide sequences at the 5' end of actin genes in Dictyostelium discoideum.

Authors: R A Firtel; R Timm; A R Kimmel; M McKeown
Journal: Proc Natl Acad Sci U S A Date: 1979-12 Impact factor: 11.205

2. A family of short, interspersed repeat sequences at the 5' end of a set of Dictyostelium single-copy mRNAs.

Authors: A R Kimmel; R A Firtel
Journal: Cell Date: 1979-04 Impact factor: 41.582

3. Intervening sequences in a Dictyostelium gene that encodes a low abundance class mRNA.

Authors: A R Kimmel; R A Firtel
Journal: Nucleic Acids Res Date: 1980-12-11 Impact factor: 16.971

4. The ovalbumin gene-sequence of putative control regions.

Authors: C Benoist; K O'Hare; R Breathnach; P Chambon
Journal: Nucleic Acids Res Date: 1980-01-11 Impact factor: 16.971

5. The structure and evolution of the human beta-globin gene family.

Authors: A Efstratiadis; J W Posakony; T Maniatis; R M Lawn; C O'Connell; R A Spritz; J K DeRiel; B G Forget; S M Weissman; J L Slightom; A E Blechl; O Smithies; F E Baralle; C C Shoulders; N J Proudfoot
Journal: Cell Date: 1980-10 Impact factor: 41.582

6. Specific in vitro transcription of conalbumin gene is drastically decreased by single-point mutation in T-A-T-A box homology sequence.

Authors: B Wasylyk; R Derbyshire; A Guy; D Molko; A Roget; R Téoule; P Chambon
Journal: Proc Natl Acad Sci U S A Date: 1980-12 Impact factor: 11.205

7. Are snRNPs involved in splicing?

Authors: M R Lerner; J A Boyle; S M Mount; S L Wolin; J A Steitz
Journal: Nature Date: 1980-01-10 Impact factor: 49.962

8. BKV splice sequences based on analysis of preferred donor and acceptor sites.

Authors: I Seif; G Khoury; R Dhar
Journal: Nucleic Acids Res Date: 1979-07-25 Impact factor: 16.971

9. Cromatin and core particles formed from the inner histones and synthetic polydeoxyribonucleotides of defined sequence.

Authors: R T Simpson; P Künzler
Journal: Nucleic Acids Res Date: 1979-04 Impact factor: 16.971

10. Dictyostelium small nuclear RNA D2 is homologous to rat nucleolar RNA U3 and is encoded by a dispersed multigene family.

Authors: J A Wise; A M Weiner
Journal: Cell Date: 1980-11 Impact factor: 41.582

52 in total

1. Identification of Dictyostelium G alpha genes expressed during multicellular development.

Authors: J A Hadwiger; T M Wilkie; M Strathmann; R A Firtel
Journal: Proc Natl Acad Sci U S A Date: 1991-09-15 Impact factor: 11.205

2. Sequence organization and developmental expression of an interspersed, repetitive element and associated single-copy DNA sequences in Dictyostelium discoideum.

Authors: A R Kimmel; R A Firtel
Journal: Mol Cell Biol Date: 1985-08 Impact factor: 4.272

3. Expression and organization of BP74, a cyclic AMP-regulated gene expressed during Dictyostelium discoideum development.

Authors: S B Hopkinson; R S Pollenz; I Drummond; R L Chisholm
Journal: Mol Cell Biol Date: 1989-10 Impact factor: 4.272

7. Identification and characterization of multiple A/T-rich cis-acting elements that control expression from Dictyostelium actin promoters: the Dictyostelium actin upstream activating sequence confers growth phase expression and has enhancer-like properties.

Authors: R Hori; R A Firtel
Journal: Nucleic Acids Res Date: 1994-11-25 Impact factor: 16.971