Literature DB >> 6825770

Synthesis of [1-Aib]-angiotensin II, an analogue with higher potency than [1-Asn,5-Val]-angiotensin II.

P Cordopatis, D Theodoropoulos.   

Abstract

[1-Aib]-angiotensin II was synthesized by Merrifield's solid-phase procedure. The analogue, tested on rabbit aorta strips, showed intrinsic activity alpha E = 1, and when tested on rat blood pressure it gave a pD2 of 8.06; a 3.2 +/- 1.3-fold higher potency than the Ciba-Hypertensin standard.

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Year:  1983        PMID： 6825770     DOI： 10.1007/bf01960656

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  Synthesis of angiotensin II antagonists by incorporating alpha-methylalanine or O-methylthreonine residues in angiotension II analogues.

Authors:  M C Khosla; H Muñoz-Ramírez; M M Hall; P A Khairallah; F M Bumpus
Journal:  J Med Chem       Date:  1977-08       Impact factor: 7.446

2.  Myotropic actions of angiotensin and noradrenaline in strips of rabbit aortae.

Authors:  J St-Louis; D Regoli; J Barabé; W K Park
Journal:  Can J Physiol Pharmacol       Date:  1977-10       Impact factor: 2.273

3.  Factors that influence the antagonistic properties of angiotensin II antagonists.

Authors:  M C Khosla; M M Hall; R R Smeby; F M Bumpus
Journal:  J Med Chem       Date:  1973-07       Impact factor: 7.446

4.  Angiotensin analogs: the influence of sarcosine substituted in position 1.

Authors:  M M Hall; M C Khosla; P A Khairallah; F M Bumpus
Journal:  J Pharmacol Exp Ther       Date:  1974-01       Impact factor: 4.030

Review 5.  Pharmacology of angiotensin.

Authors:  D Regoli; W K Park; F Rioux
Journal:  Pharmacol Rev       Date:  1974-06       Impact factor: 25.468

6.  Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides.

Authors:  E Kaiser; R L Colescott; C D Bossinger; P I Cook
Journal:  Anal Biochem       Date:  1970-04       Impact factor: 3.365

7.  Pressor action of beta blocking agents in rats.

Authors:  D Regoli
Journal:  Can J Physiol Pharmacol       Date:  1970-07       Impact factor: 2.273

8.  Synthesis and pharmacological properties of [1-N4-dimethyl-asparagine]-angiotensin II.

Authors:  P Cordopatis; J Brison; J Dirkx; D Theodoropoulos
Journal:  Experientia       Date:  1979-07-15

9.  Synthesis of [alpha-methyltyrosine-4]angiotensin II: studies of its conformation, pressor activity, and mode of enzymatic degradation.

Authors:  M C Khosla; K Stachowiak; R R Smeby; F M Bumpus; F Piriou; K Lintner; S Fermandjian
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

10.  Studies on position 1 of angiotensin II: effects on affinity and duration of action from alkyl amide substitution.

Authors:  P Cordopatis; D Theodoropoulos; G Guillemette; E Escher
Journal:  J Med Chem       Date:  1981-02       Impact factor: 7.446
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  3 in total

1.  Changes in residues 1 and 4 of angiotensin II affect differently its agonist and tachyphylactic properties.

Authors:  S I Shimuta; C R Nakaie; A C Paiva; P Cordopatis; D Theodoropoulos
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-09       Impact factor: 3.000

2.  High-performance liquid chromatographic resolution of (R, S)-α-alkyl-α-amino acids as diastereomeric derivatives.

Authors:  H Brückner; S Zivny
Journal:  Amino Acids       Date:  1993-02       Impact factor: 3.520

3.  Conformational Properties of Seven Toac-Labeled Angiotensin I Analogues Correlate with Their Muscle Contraction Activity and Their Ability to Act as ACE Substrates.

Authors:  Luis Gustavo D Teixeira; Luciana Malavolta; Patrícia A Bersanetti; Shirley Schreier; Adriana K Carmona; Clovis R Nakaie
Journal:  PLoS One       Date:  2015-08-28       Impact factor: 3.240
  3 in total

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