Literature DB >> 477828

Synthesis and pharmacological properties of [1-N4-dimethyl-asparagine]-angiotensin II.

P Cordopatis, J Brison, J Dirkx, D Theodoropoulos.   

Abstract

[1-N4-Dimethyl-asparagine]-angiotensin II was synthesized by Merrifield's solid-phase procedure. The analogue gave rat blood pressure about 70% relative potency to Hypertension (Ciba). Rabbit aorta strips gave intrinsic activity alpha E = 1, a PD2 of 6.92 +/- 0.09 and an affinity relative to [Asn1]-angiotensin II of 6.5%.

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Year:  1979        PMID： 477828     DOI： 10.1007/bf01955103

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Myotropic actions of angiotensin and noradrenaline in strips of rabbit aortae.

Authors:  J St-Louis; D Regoli; J Barabé; W K Park
Journal:  Can J Physiol Pharmacol       Date:  1977-10       Impact factor: 2.273

2.  Synthesis of analogs of (8-isoleucine)angiotensin II with variations in position 1.

Authors:  M C Khosla; M M Hall; R R Smeby; F M Bumpus
Journal:  J Med Chem       Date:  1974-04       Impact factor: 7.446

3.  Factors that influence the antagonistic properties of angiotensin II antagonists.

Authors:  M C Khosla; M M Hall; R R Smeby; F M Bumpus
Journal:  J Med Chem       Date:  1973-07       Impact factor: 7.446

4.  Angiotensin analogs: the influence of sarcosine substituted in position 1.

Authors:  M M Hall; M C Khosla; P A Khairallah; F M Bumpus
Journal:  J Pharmacol Exp Ther       Date:  1974-01       Impact factor: 4.030

5.  Improvement to the esterification procedure used in solid phase peptide synthesis.

Authors:  A Loffet
Journal:  Int J Protein Res       Date:  1971

6.  Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides.

Authors:  E Kaiser; R L Colescott; C D Bossinger; P I Cook
Journal:  Anal Biochem       Date:  1970-04       Impact factor: 3.365

7.  Pressor action of beta blocking agents in rats.

Authors:  D Regoli
Journal:  Can J Physiol Pharmacol       Date:  1970-07       Impact factor: 2.273

8.  Use of anhydrous hydrogen fluoride in peptide synthesis. I. Behavior of various protective groups in anhydrous hydrogen fluoride.

Authors:  S Sakakibara; Y Shimonishi; Y Kishida; M Okada; H Sugihara
Journal:  Bull Chem Soc Jpn       Date:  1967-09       Impact factor: 5.488
  8 in total
  1 in total

1.  Synthesis of [1-Aib]-angiotensin II, an analogue with higher potency than [1-Asn,5-Val]-angiotensin II.

Authors:  P Cordopatis; D Theodoropoulos
Journal:  Experientia       Date:  1983-01-15
  1 in total

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