| Literature DB >> 6825717 |
R G Nagele, J F Pietrolungo, M C Kosciuk, H Lee, F J Roisen.
Abstract
Diazepam (Valium/Roche), a benzodiazepine derivative, reversibly inhibited the spreading of chick embryo fibroblasts in a dose-related manner. This inhibition was accompanied by: 1 Fewer and less organized microfilament bundles. 2 A reduction in myosin fluorescence along these structures. 3 A reduction in the total myosin content of cells compared to corresponding controls. Overall results suggest that myosin plays an active role in the spreading of chick embryo fibroblasts.Entities:
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Year: 1983 PMID： 6825717 DOI： 10.1016/0014-4827(83)90117-9
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905