Literature DB >> 3743723

The antimitotic activities of some benzodiazepines.

A Miernik, A Santa-Maria, F Marano.   

Abstract

Among 9 benzodiazepines, tested on the proliferation of synchronously dividing flagellate cells, only diazepam and medazepam can induce an accumulation of abnormal mitotic figures after 24 h of treatment. It seems that there is not a direct relation between the activity of benzodiazepines on the central nervous system and their ability to inhibit mitosis.

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Year:  1986        PMID： 3743723     DOI： 10.1007/bf01941778

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  6 in total

1.  Tranquillizers can block mitogenesis in 3T3 cells and induce differentiation in Friend cells.

Authors:  G D Clarke; P J Ryan
Journal:  Nature       Date:  1980-09-11       Impact factor: 49.962

2.  Diazepam induces mitotic arrest at prometaphase by inhibiting centriolar separation.

Authors:  L C Andersson; V P Lehto; S Stenman; R A Badley; I Virtanen
Journal:  Nature       Date:  1981-05-21       Impact factor: 49.962

3.  Benzodiazepines that bind at peripheral sites inhibit cell proliferation.

Authors:  J K Wang; J I Morgan; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

4.  Effects of diazepam on mitosis and basal body duplication of synchronously dividing flagellate cells.

Authors:  F Marano; A Santa-Maria; W Fries
Journal:  Biol Cell       Date:  1984       Impact factor: 4.458

5.  Diazepam inhibits the spreading of chick embryo fibroblasts.

Authors:  R G Nagele; J F Pietrolungo; M C Kosciuk; H Lee; F J Roisen
Journal:  Exp Cell Res       Date:  1983-01       Impact factor: 3.905

6.  Aneuploidy induction by mitotic arrestants. Effects of diazepam on diploid Chinese hamster cells.

Authors:  T C Hsu; J C Liang; L R Shirley
Journal:  Mutat Res       Date:  1983-11       Impact factor: 2.433
  6 in total
  1 in total

1.  Effect of benzodiazepines on the proliferation of mouse spleen lymphocytes in vitro.

Authors:  M Pawlikowski; K Lysoń; J Kunert-Radek; H Stepień
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575
  1 in total

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