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Literature DB >> 6825363

Lidocaine toxicity from topical mucosal application. With a review of the clinical pharmacology of lidocaine.

H C Mofenson, T R Caraccio, H Miller, J Greensher.

Abstract

A case is reported of an infant who experienced seizures while being treated with a topical lidocaine 2% solution (Xylocaine 2% Viscous) for teething. The pharmacology of lidocaine is reviewed to alert physicians to the potential dangers of topical mucosal application of these preparations.

Entities: Chemical Disease Species

Mesh：

Substances：
Lidocaine

Year: 1983 PMID： 6825363 DOI： 10.1177/000992288302200306

Source DB: PubMed Journal: Clin Pediatr (Phila) ISSN： 0009-9228 Impact factor: 1.168

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Cited

11 in total

1. Central nervous system toxicity following topical skin application of lidocaine.

Authors: Tal Brosh-Nissimov; Merav Ingbir; Iris Weintal; Mordechai Fried; Reuven Porat
Journal: Eur J Clin Pharmacol Date: 2004-10-02 Impact factor: 2.953

2. Intractable seizures in a toddler after application of an over-the-counter local anesthetic cream.

Authors: Syed Hoda; Jennifer O'Brien; Jonathan Gamble
Journal: CMAJ Date: 2016-04-25 Impact factor: 8.262

3. Seizures after intraurethral instillation of lidocaine.

Authors: M B Sundaram
Journal: CMAJ Date: 1987-08-01 Impact factor: 8.262

4. Local Anesthetic Systemic Toxicity Induced Cardiac Arrest After Topicalization for Transesophageal Echocardiography and Subsequent Treatment With Extracorporeal Cardiopulmonary Resuscitation.

Authors: Brandon Bacon; Natalie Silverton; Micah Katz; Elise Heath; David A Bull; Jason Harig; Joseph E Tonna
Journal: J Cardiothorac Vasc Anesth Date: 2018-01-31 Impact factor: 2.628

Lidocaine toxicity from topical mucosal application. With a review of the clinical pharmacology of lidocaine.

1. Central nervous system toxicity following topical skin application of lidocaine.

2. Intractable seizures in a toddler after application of an over-the-counter local anesthetic cream.

3. Seizures after intraurethral instillation of lidocaine.

4. Local Anesthetic Systemic Toxicity Induced Cardiac Arrest After Topicalization for Transesophageal Echocardiography and Subsequent Treatment With Extracorporeal Cardiopulmonary Resuscitation.

Review 5. A risk-benefit assessment of topical percutaneous local anaesthetics in children.

6. Pharmacokinetics of lidocaine delivered from a transmucosal patch in children.

7. Seizures due to lidocaine toxicity in a child during cardiac catheterization.

8. Lidocaine treatment of neonatal convulsions, a therapeutic dilemma.

9. Infant with status epilepticus secondary to systemic lidocaine toxicity from topical application.

10. Lignocaine toxicity after anterior nasal packing.