Literature DB >> 2776817

Lidocaine treatment of neonatal convulsions, a therapeutic dilemma.

A Wallin1, A Nergårdh, P A Hynning.   

Abstract

Three infants with neonatal convulsions were given lidocaine infusions for three days, three weeks and three months, respectively, and the plasma concentrations of lidocaine and its metabolites were analyzed by HPLC. After a prolonged infusion there was considerable accumulation of the metabolites. This may account for the difficulty of stopping the infusion without relapse of the seizures.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2776817     DOI： 10.1007/BF00637740

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  13 in total

1.  The convulsant potency of lidocaine and its N-dealkylated metabolites.

Authors:  J Blumer; J M Strong; A J Atkinson
Journal:  J Pharmacol Exp Ther       Date:  1973-07       Impact factor: 4.030

2.  Seizures induced by oral viscous lidocaine.

Authors:  M J Giard; D L Uden; D J Whitlock; D M Watson
Journal:  Clin Pharm       Date:  1983 Mar-Apr

3.  Prolonged seizures associated with the use of viscous lidocaine.

Authors:  P Rothstein; J Dornbusch; B A Shaywitz
Journal:  J Pediatr       Date:  1982-09       Impact factor: 4.406

4.  Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidide.

Authors:  J M Strong; D E Mayfield; A J Atkinson; B C Burris; F Raymon; L T Webster
Journal:  Clin Pharmacol Ther       Date:  1975-02       Impact factor: 6.875

5.  Maternal, fetal, and neonatal metabolism of lidocaine.

Authors:  B R Kuhnert; D R Knapp; P M Kuhnert; A L Prochaska
Journal:  Clin Pharmacol Ther       Date:  1979-08       Impact factor: 6.875

6.  Age-dependent lidocaine disposition in patients with acute myocardial infarction.

Authors:  J Cusson; S Nattel; C Matthews; M Talajic; S Lawand
Journal:  Clin Pharmacol Ther       Date:  1985-04       Impact factor: 6.875

7.  Influence of long-term infusions on lidocaine kinetics.

Authors:  L A Bauer; T Brown; M Gibaldi; L Hudson; S Nelson; V Raisys; J P Shea
Journal:  Clin Pharmacol Ther       Date:  1982-04       Impact factor: 6.875

8.  Plasma lignocaine concentrations following topical laryngeal application.

Authors:  R L Eyres; W Bishop; R C Oppenheim; T C Brown
Journal:  Anaesth Intensive Care       Date:  1983-02       Impact factor: 1.669

9.  Lidocaine toxicity from topical mucosal application. With a review of the clinical pharmacology of lidocaine.

Authors:  H C Mofenson; T R Caraccio; H Miller; J Greensher
Journal:  Clin Pediatr (Phila)       Date:  1983-03       Impact factor: 1.168

10.  Maternal, fetal, and neonatal lidocaine levels following local perineal infiltration.

Authors:  E H Philipson; B R Kuhnert; C D Syracuse
Journal:  Am J Obstet Gynecol       Date:  1984-06-15       Impact factor: 8.661
View more
  3 in total

Review 1.  Neonatal seizures.

Authors:  D Evans; M Levene
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  1998-01       Impact factor: 5.747

2.  Cardiac arrhythmias in neonates receiving lidocaine as anticonvulsive treatment.

Authors:  Linda G M van Rooij; Mona C Toet; Karin M A Rademaker; Floris Groenendaal; Linda S de Vries
Journal:  Eur J Pediatr       Date:  2004-08-07       Impact factor: 3.183

3.  A systematic review of the pharmacokinetics of antiepileptic drugs in neonates with refractory seizures.

Authors:  Joanie K Tulloch; Roxane R Carr; Mary H H Ensom
Journal:  J Pediatr Pharmacol Ther       Date:  2012-01
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.