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Literature DB >> 6824796

Studies on the mechanism of PMN activation III. by lymphokines.

Abstract

The influence of a guinea pig lymphokine preparation on the oxidative metabolism of human and guinea pig granulocytes of various sources was investigated. A dose-dependent increase of the oxidative burst following lymphokine challenge was observed. It occurred in unstimulated guinea pig peripheral polymorphonuclear leukocytes (PMN) and in prestimulated PMN obtained from the peritoneal cavity after glycogen injection as well. The lymphokine effect on the oxidative metabolism is not species-restricted because the guinea pig lymphokine preparation elicits an oxidative burst in human PMN, too. The increase caused by lymphokines is nearly of the same order of magnitude as that obtained with zymosan.

Entities: Chemical Species

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Year: 1983 PMID： 6824796 DOI： 10.1007/bf00320274

Source DB: PubMed Journal: Blut ISSN： 0006-5242

12 in total

1. Studies on the effect of soluble lymphocyte products (lymphokines) on macrophage physiology. I. Early changes in enzyme activity and permeability.

Authors: L W Poulter; J L Turk
Journal: Cell Immunol Date: 1975-11 Impact factor: 4.868

2. Studies on the effect of soluble lymphocyte products (lymphokines) on macrophage physiology. II. Cytochemical changes associated with activation.

Authors: L W Poulter; J L Turk
Journal: Cell Immunol Date: 1975-11 Impact factor: 4.868

1. Silibinin (Legalon-70) enhances the motility of human neutrophils immobilized by formyl-tripeptide, calcium ionophore, lymphokine and by normal human serum.

Authors: L Kalmár; J Kádár; A Somogyi; P Gergely; G Csomós; J Fehér
Journal: Agents Actions Date: 1990-03

1 in total

Studies on the mechanism of PMN activation III. by lymphokines.

1. Studies on the effect of soluble lymphocyte products (lymphokines) on macrophage physiology. I. Early changes in enzyme activity and permeability.

2. Studies on the effect of soluble lymphocyte products (lymphokines) on macrophage physiology. II. Cytochemical changes associated with activation.

3. In vitro quantitation of cell-mediated immunity in guinea-pigs by macrophage reduction of nitro-blue tetrazolium.

4. Studies on the mechanism of PMN activation. I. By dextran sulfates.

5. Stimulation of human neutrophil leukocyte aerobic glucose metabolism by purified chemotactic factors.

6. Specific release of neutrophillic- and eosinophilic-stimulating factors from sensitized lymphocytes.

7. Studies on the mechanism of PMN activation. II. By triggering the alternative pathway of complement activation.

8. Increased nitroblue tetrazolium dye reduction by human neutrophils stimulated by interferon in vitro.

9. Products of activated lymphocytes: leukocyte inhibitory factor (LIF) distinct from migration inhibitory factor (MIF).

10. Alterations of macrophage functions by mediators from lymphocytes.

1. Silibinin (Legalon-70) enhances the motility of human neutrophils immobilized by formyl-tripeptide, calcium ionophore, lymphokine and by normal human serum.