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Literature DB >> 5576335

Alterations of macrophage functions by mediators from lymphocytes.

Abstract

Sensitized lymphocytes were incubated in vitro with the specific antigen Supernatants from these cultures were chromatographed on Sephadex G-100 columns. Supernatant fractions containing MIF, chemotactic factor, and lymphotoxin, but free of antigen and antibody, were incubated with normal peritoneal exudate macrophages. Macrophage adherence, phagocytosis, spreading, motility, and direct hexose monophosphate oxidation were enhanced, while protein synthesis was unaffected. Thus, antigen-stimulated lymphocytes secrete a factor or factors which enhance certain macrophage functions. Implications for models of cellular immunity and cellular hypersensitivity are discussed.

Entities: Chemical Disease Gene

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Year: 1971 PMID： 5576335 PMCID： PMC2138934 DOI： 10.1084/jem.133.6.1356

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

50 in total

1. Studies on the fate of antigens in vitro. I. The effect of specific antibody on the fate of I 131 trace labeled human serum albumin in vitro in the presence of guinea pig monocytes.

Authors: E SORKIN; S V BOYDEN
Journal: J Immunol Date: 1959-04 Impact factor: 5.422

2. The carbon metabolism of the tubercle bacillus; studies with isotopic carbon.

Authors: E R LONG; R J ANDERSON; D RITTENBERG; M L KARNOVSKY; H J HENDERSON
Journal: Am Rev Tuberc Date: 1955-05

3. The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes.

Authors: A J SBARRA; M L KARNOVSKY
Journal: J Biol Chem Date: 1959-06 Impact factor: 5.157

4. The role of the phagocyte in host-parasite interactions. 13. The direct quantitative estimation of H2O2 in phagocytizing cells.

Authors: B Paul; A J Sbarra
Journal: Biochim Biophys Acta Date: 1968-02-01

5. Metabolic and morphological observations on the effect of surface-active agents of leukocytes.

Authors: R C Graham; M J Karnovsky; A W Shafer; E A Glass; M L Karnovsky
Journal: J Cell Biol Date: 1967-03 Impact factor: 10.539

6. Function of h(2)o(2), myeloperoxidase, and hexose monophosphate shunt enzymes in phagocytizing cells from different species.

Authors: B B Paul; R R Strauss; A A Jacobs; A J Sbarra
Journal: Infect Immun Date: 1970-04 Impact factor: 3.441

Alterations of macrophage functions by mediators from lymphocytes.

1. Studies on the fate of antigens in vitro. I. The effect of specific antibody on the fate of I 131 trace labeled human serum albumin in vitro in the presence of guinea pig monocytes.

2. The carbon metabolism of the tubercle bacillus; studies with isotopic carbon.

3. The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes.

4. The role of the phagocyte in host-parasite interactions. 13. The direct quantitative estimation of H2O2 in phagocytizing cells.

5. Metabolic and morphological observations on the effect of surface-active agents of leukocytes.

6. Function of h(2)o(2), myeloperoxidase, and hexose monophosphate shunt enzymes in phagocytizing cells from different species.

7. Demonstration in tissue culture of lymphocyte-mediated immunity to tuberculosis.

8. The influence of immunologically committed lymphoid cells on macrophage activity in vivo.

9. Iodination of bacteria: a bactericidal mechanism.

10. THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE.

Review 1. Cytokines: past, present, and future.

2. Activation of human blood monocytes by products of sensitized lymphocytes.

3. Mediation of macrophage effector function by lymphokine.

4. Lymphokine-induced production and release of lysosomal enzymes by macrophages.

5. Monocyte activation in horses persistently infected with equine infectious anemia virus.

6. Proceedings: In vitro methods assessing the physiological activation of macrophages in vivo.

7. Different effects of phytohemagglutinin-activated lymphocytes and their culture supernatants on macrophage function.

8. Effect of methylprednisolone on some BCG-mediated changes in rabbit alveolar macrophage.

9. Effect of human monocytes and macrophages on Trypanosoma cruzi.

10. Cellular immunity in vitro: migration inhibition and phagocytosis.