Literature DB >> 6824341

Effect of carbohydrate on protein solubility.

E Q Lawson, B E Hedlund, M E Ericson, D A Mood, G W Litman, R Middaugh.   

Abstract

The effect of covalently attached carbohydrate on the solubility of a number of proteins has been examined by the PEG precipitation technique. Both increases and decreases in solubility are observed depending on the state of glycosylation, the type of protein, and temperature. It is concluded from this data and associated apparent thermodynamic parameters that a general role for carbohydrate in the solubilization of proteins is not currently experimentally supportable.

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Year:  1983        PMID: 6824341     DOI: 10.1016/0003-9861(83)90449-6

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN: 0003-9861            Impact factor:   4.013


  6 in total

1.  The influence of N-acetylneuraminic acid on the properties of human orosomucoid.

Authors:  M L Friedman; J R Wermeling; H B Halsall
Journal:  Biochem J       Date:  1986-05-15       Impact factor: 3.857

2.  Carbohydrate and protein conformation.

Authors:  D C Kilpatrick
Journal:  Biochem J       Date:  1986-11-01       Impact factor: 3.857

Review 3.  Effects of glycosylation on the stability of protein pharmaceuticals.

Authors:  Ricardo J Solá; Kai Griebenow
Journal:  J Pharm Sci       Date:  2009-04       Impact factor: 3.534

4.  IgG3 cryoglobulins in autoimmune MRL-lpr/lpr mice: immunopathogenesis, therapeutic approaches and relevance to similar human diseases.

Authors:  S Izui; T Berney; T Shibata; T Fulpius
Journal:  Ann Rheum Dis       Date:  1993-03       Impact factor: 19.103

Review 5.  Glycosylated Biotherapeutics: Immunological Effects of N-Glycolylneuraminic Acid.

Authors:  Sharon Yehuda; Vered Padler-Karavani
Journal:  Front Immunol       Date:  2020-01-23       Impact factor: 7.561

6.  Glycosylation of a Nonfibrillizing Appendage Alters the Self-Assembly Pathway of a Synthetic β-Sheet Fibrillizing Peptide.

Authors:  Ran Zuo; Renjie Liu; Juanpablo Olguin; Gregory A Hudalla
Journal:  J Phys Chem B       Date:  2021-06-15       Impact factor: 3.466

  6 in total

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