Literature DB >> 6822877

Radiotoxicity of thallium-201 in mouse testes: inadequacy of conventional dosimetry.

D V Rao, G F Govelitz, K S Sastry.   

Abstract

When TI-201 is concentrated in mouse testes, the low-energy Auger electrons following its electron-capture decay are found to be much more effective in causing loss of testicular weight and reduction of sperm heads than the energetic beta particles from similarly distributed TI-204. These results are contrary to expectations based on conventional dosimetry of tissue-incorporated radionuclides, and point to possible underestimation of risks by the currently adopted dosimetric procedures, especially in the case of radionuclides decaying by electron capture and internal conversion.

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Year:  1983        PMID: 6822877

Source DB:  PubMed          Journal:  J Nucl Med        ISSN: 0161-5505            Impact factor:   10.057


  12 in total

1.  Induction of sperm head abnormalities by incorporated radionuclides: dependence on subcellular distribution, type of radiation, dose rate, and presence of radioprotectors.

Authors:  D V Rao; V R Narra; R W Howell; V K Lanka; K S Sastry
Journal:  Radiat Res       Date:  1991-01       Impact factor: 2.841

Review 2.  Auger electron emitters: insights gained from in vitro experiments.

Authors:  G Makrigiorgos; S J Adelstein; A I Kassis
Journal:  Radiat Environ Biophys       Date:  1990       Impact factor: 1.925

3.  In-vivo radiotoxicity of DNA-incorporated 125I compared with that of densely ionising alpha-particles.

Authors:  D V Rao; V R Narra; R W Howell; G F Govelitz; K S Sastry
Journal:  Lancet       Date:  1989-09-16       Impact factor: 79.321

4.  Global fallout distribution in fireplace ashes.

Authors:  B A Burrows; T C Chalmers; J A Cardarelli
Journal:  Trans Am Clin Climatol Assoc       Date:  1989

5.  On the equivalent dose for Auger electron emitters.

Authors:  R W Howell; V R Narra; K S Sastry; D V Rao
Journal:  Radiat Res       Date:  1993-04       Impact factor: 2.841

Review 6.  Radionuclide targeting and dosimetry at the microscopic level: the role of microautoradiography.

Authors:  M R Puncher; P J Blower
Journal:  Eur J Nucl Med       Date:  1994-12

7.  Relative biological effectiveness of alpha-particle emitters in vivo at low doses.

Authors:  R W Howell; M T Azure; V R Narra; D V Rao
Journal:  Radiat Res       Date:  1994-03       Impact factor: 2.841

8.  Radiotoxicity of gadolinium-148 and radium-223 in mouse testes: relative biological effectiveness of alpha-particle emitters in vivo.

Authors:  R W Howell; S M Goddu; V R Narra; D R Fisher; R E Schenter; D V Rao
Journal:  Radiat Res       Date:  1997-03       Impact factor: 2.841

9.  In vitro proof of concept studies of radiotoxicity from Auger electron-emitter thallium-201.

Authors:  Vincenzo Abbate; Samantha Y A Terry; Katarzyna M Osytek; Philip J Blower; Ines M Costa; Gareth E Smith
Journal:  EJNMMI Res       Date:  2021-07-05       Impact factor: 3.138

Review 10.  Auger processes in the 21st century.

Authors:  Roger W Howell
Journal:  Int J Radiat Biol       Date:  2008-12       Impact factor: 2.694

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