Literature DB >> 2570902

In-vivo radiotoxicity of DNA-incorporated 125I compared with that of densely ionising alpha-particles.

D V Rao1, V R Narra, R W Howell, G F Govelitz, K S Sastry.   

Abstract

When the atomic nucleus of 125I decays by orbital electron capture followed by internal conversion, numerous very-low-energy electrons (Auger electrons) are emitted, so that the energy density in the immediate vicinity of the decay site is extremely high. 125I incorporated into DNA was as effective as densely ionising 5.3 MeV alpha-particles from 210Po in reducing the sperm-head population in mice. Hence the biological risks of Auger-electron emitting radionuclides widely used in biology and medicine ought to be reassessed.

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Year:  1989        PMID： 2570902      PMCID： PMC8172252          DOI： 10.1016/s0140-6736(89)90896-9

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  21 in total

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Authors:  E F OAKBERG
Journal:  Am J Anat       Date:  1956-11

2.  Forum on the microdosimetry of radiopharmaceuticals. Committee on Effects of Ionising Radiation. London, 27 may 1985. Abstracts.

Authors: 
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1986-09

3.  Kinetics of uptake, retention, and radiotoxicity of 125IUdR in mammalian cells: implications of localized energy deposition by Auger processes.

Authors:  A I Kassis; K S Sastry; S J Adelstein
Journal:  Radiat Res       Date:  1987-01       Impact factor: 2.841

4.  The range of high LET effects from 125I decays.

Authors:  D E Charlton
Journal:  Radiat Res       Date:  1986-08       Impact factor: 2.841

5.  Absorption of 20-eV to 50,000-eV electron beams in air and plastic.

Authors:  A Cole
Journal:  Radiat Res       Date:  1969-04       Impact factor: 2.841

6.  The in vitro radiobiology of astatine-211 decay.

Authors:  A I Kassis; C R Harris; S J Adelstein; T J Ruth; R Lambrecht; A P Wolf
Journal:  Radiat Res       Date:  1986-01       Impact factor: 2.841

7.  Mutation and inactivation of mammalian cells by various ionising radiations.

Authors:  R Cox; J Thacker; D T Goodhead; R J Munson
Journal:  Nature       Date:  1977-06-02       Impact factor: 49.962

8.  Lethality of Auger electrons from the decay of bromine-77 in the DNA of mammalian cells.

Authors:  A I Kassis; S J Adelstein; C Haydock; K S Sastry; K D McElvany; M J Welch
Journal:  Radiat Res       Date:  1982-05       Impact factor: 2.841

9.  In vivo effects of iron-55 and iron-59 on mouse testes: biophysical dosimetry of Auger electrons.

Authors:  D V Rao; K S Sastry; G F Govelitz; H E Grimmond; H Z Hill
Journal:  J Nucl Med       Date:  1985-12       Impact factor: 10.057

10.  Reduction in sperm levels after testicular irradiation of the mouse: a comparison with man.

Authors:  M L Meistrich; R C Samuels
Journal:  Radiat Res       Date:  1985-04       Impact factor: 2.841
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  20 in total

1.  Bystander effects caused by nonuniform distributions of DNA-incorporated (125)I.

Authors:  Roger W Howell; Anupam Bishayee
Journal:  Micron       Date:  2002       Impact factor: 2.251

2.  Cytotoxicity, genotoxicity and intracellular distribution of the Auger electron emitter (65)Zn in two human cell lines.

Authors:  Ralf Kriehuber; Manuela Riedling; Myrtill Simkó; Dieter G Weiss
Journal:  Radiat Environ Biophys       Date:  2004-04-23       Impact factor: 1.925

3.  A model for optimizing delivery of targeted radionuclide therapies into resection cavity margins for the treatment of primary brain cancers.

Authors:  Raghu Raghavan; Roger W Howell; Michael R Zalutsky
Journal:  Biomed Phys Eng Express       Date:  2017-05-05

4.  Induction of sperm head abnormalities by incorporated radionuclides: dependence on subcellular distribution, type of radiation, dose rate, and presence of radioprotectors.

Authors:  D V Rao; V R Narra; R W Howell; V K Lanka; K S Sastry
Journal:  Radiat Res       Date:  1991-01       Impact factor: 2.841

Review 5.  Auger radiation targeted into DNA: a therapy perspective.

Authors:  Franz Buchegger; Florence Perillo-Adamer; Yves M Dupertuis; Angelika Bischof Delaloye
Journal:  Eur J Nucl Med Mol Imaging       Date:  2006-08-08       Impact factor: 9.236

6.  On the equivalent dose for Auger electron emitters.

Authors:  R W Howell; V R Narra; K S Sastry; D V Rao
Journal:  Radiat Res       Date:  1993-04       Impact factor: 2.841

7.  Biological effect of lead-212 localized in the nucleus of mammalian cells: role of recoil energy in the radiotoxicity of internal alpha-particle emitters.

Authors:  M T Azure; R D Archer; K S Sastry; D V Rao; R W Howell
Journal:  Radiat Res       Date:  1994-11       Impact factor: 2.841

8.  Relative biological effectiveness of alpha-particle emitters in vivo at low doses.

Authors:  R W Howell; M T Azure; V R Narra; D V Rao
Journal:  Radiat Res       Date:  1994-03       Impact factor: 2.841

9.  Different contributions of the indirect effects of gamma-rays on the cytotoxicity in M10 and XRCC4 transfected M10 cells.

Authors:  Noriyuki Miyazaki; Hisako Nakano; Atsushi Ito; Kunio Shinohara
Journal:  Radiat Environ Biophys       Date:  2007-05-04       Impact factor: 1.925

10.  MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy.

Authors:  George Sgouros; John C Roeske; Michael R McDevitt; Stig Palm; Barry J Allen; Darrell R Fisher; A Bertrand Brill; Hong Song; Roger W Howell; Gamal Akabani; Wesley E Bolch; A Bertrand Brill; Darrell R Fisher; Roger W Howell; Ruby F Meredith; George Sgouros; Barry W Wessels; Pat B Zanzonico
Journal:  J Nucl Med       Date:  2010-01-15       Impact factor: 10.057
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