Literature DB >> 6822208

Thyroxine 5'-deiodinase activity in brown adipose tissue.

J L Leonard, S A Mellen, P R Larsen.   

Abstract

Homogenates of rat brown adipose tissue (BAT) and epididymal fat pad (EPI) catalyze the 5'-deiodination of 3,3',5'-triiodothyronine (rT3) in the presence of dithiothreitol. BAT, but not EPI, catalyzes the 5'-deiodination of thyroxinE (T4) generating equal amounts of 3,5,3'-triiodothyronine (T3) and iodide. BAT 5'-deiodinase activity was unaffected by propylthiouracil (PTU) and was elevated in hypothyroid rats, whereas EPI 5'-deiodinase was totally inhibited by PTU and was depressed in hypothyroidism. These results indicate that type II (PTU-insensitive) 5'-iodothyronine deiodinase activity is present in BAT.

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Year:  1983        PMID： 6822208     DOI： 10.1210/endo-112-3-1153

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  32 in total

1.  Mammary 5'deiodinase (5'D) during the breeding cycle of the rat: indirect evidence that 5'D type I is specific to the alveolar epithelium.

Authors:  C Aceves; C R Fonte; I Ramirez-C; S Wilson; O Pineda-C; L Lopez-B; R Mancilla; C Valverde-R
Journal:  Endocrine       Date:  1995-02       Impact factor: 3.633

Review 2.  Thyroid hormone deiodinases revisited: insights from lungfish: a review.

Authors:  M Sutija; J M P Joss
Journal:  J Comp Physiol B       Date:  2005-09-08       Impact factor: 2.200

Review 3.  Regulatory circuits controlling white versus brown adipocyte differentiation.

Authors:  Jacob B Hansen; Karsten Kristiansen
Journal:  Biochem J       Date:  2006-09-01       Impact factor: 3.857

4.  Iodothyronine 5'-deiodinase activity as an early event of prenatal brown-fat differentiation in bovine development.

Authors:  M Giralt; L Casteilla; O Viñas; T Mampel; R Iglesias; J Robelin; F Villarroya
Journal:  Biochem J       Date:  1989-04-15       Impact factor: 3.857

5.  Iodothyronine 5'-deiodinase activity and thyroid hormone content in brown adipose tissue during the breeding cycle of the rat.

Authors:  O Viñas; M Giralt; M J Obregón; R Iglesias; F Villarroya; T Mampel
Journal:  Biochem J       Date:  1988-10-15       Impact factor: 3.857

6.  Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots.

Authors:  Bingzhong Xue; Ann Coulter; Jong Seop Rim; Robert A Koza; Leslie P Kozak
Journal:  Mol Cell Biol       Date:  2005-09       Impact factor: 4.272

7.  Interrelationship between 3,5,3´-triiodothyronine and the circadian clock in the rodent heart.

Authors:  Rodrigo Antonio Peliciari-Garcia; Rafael Maso Prévide; Maria Tereza Nunes; Martin Elliot Young
Journal:  Chronobiol Int       Date:  2016-09-23       Impact factor: 2.877

8.  Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue.

Authors:  A C Bianco; J E Silva
Journal:  J Clin Invest       Date:  1987-01       Impact factor: 14.808

9.  Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats.

Authors:  J E Silva; M B Gordon; F R Crantz; J L Leonard; P R Larsen
Journal:  J Clin Invest       Date:  1984-04       Impact factor: 14.808

10.  Characteristics of thyroxine 5'-deiodination in cultured human placental cells. Regulation by iodothyronines.

Authors:  J T Hidal; M M Kaplan
Journal:  J Clin Invest       Date:  1985-09       Impact factor: 14.808
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