Literature DB >> 6819250

Comparison of the effectiveness of several formulations of sodium valproate: tablets, enteric-coated capsules, solutions and rectal capsules.

D Battino, M Biraghi, C Cusi, A Nespolo, G Avanzini.   

Abstract

The effects of an oral enteric-coated preparation (VAL 579 capsules) of sodium valproate (VPA) were compared with those of conventional oral and rectal preparations in 24 epileptic patients. Enteric-coated capsules are useful for avoiding gastric intolerance to VPA. Plasma VPA level peaks after the enteric- coated form were later than after other forms. The bioavailability appeared to be the same for all the forms.

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Year:  1982        PMID： 6819250     DOI： 10.1007/bf02043309

Source DB:  PubMed          Journal:  Ital J Neurol Sci        ISSN： 0392-0461


  10 in total

1.  Acute hepatic failure associated with the use of sodium valproate.

Authors:  F J Suchy; W F Balistreri; J J Buchino; J M Sondheimer; S R Bates; G L Kearns; J D Stull; K E Bove
Journal:  N Engl J Med       Date:  1979-04-26       Impact factor: 91.245

Review 2.  Clinical pharmacokinetics of valproic acid.

Authors:  R Gugler; G E von Unruh
Journal:  Clin Pharmacokinet       Date:  1980 Jan-Feb       Impact factor: 6.447

3.  Acute intoxication with sodium valproate.

Authors:  D W Chadwick; W J Cumming; I Livingstone; N E Cartlidge
Journal:  Ann Neurol       Date:  1979-12       Impact factor: 10.422

4.  Comparative steady state serum levels of valproic acid administered as two different formulations--Deprakine and Orfiril.

Authors:  S I Johannessen; O Henriksen
Journal:  Acta Neurol Scand       Date:  1979-12       Impact factor: 3.209

5.  [On the enteral absorption of valproic acid (author's transl)].

Authors:  W Oelkers; G Stoffels; H Schäfer; H Reith
Journal:  Arzneimittelforschung       Date:  1977

Review 6.  Sodium di-N-propylacetate (DPA) in the treatment of epilepsy. A review.

Authors:  D Simon; J K Penry
Journal:  Epilepsia       Date:  1975-11       Impact factor: 5.864

7.  Rectal administration of sodium valproate in status epilepticus.

Authors:  F J Vajda; G W Mihaly; J L Miles; G A Donnan; P F Bladin
Journal:  Neurology       Date:  1978-09       Impact factor: 9.910

8.  Effect of valproic acid on hepatic function.

Authors:  L J Willmore; B J Wilder; J Bruni; H J Villarreal
Journal:  Neurology       Date:  1978-09       Impact factor: 9.910

Review 9.  Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.

Authors:  R M Pinder; R N Brogden; T M Speight; G S Avery
Journal:  Drugs       Date:  1977-02       Impact factor: 9.546

10.  Disposition of valproic acid in man.

Authors:  R Gugler; A Schell; M Eichelbaum; W Fröscher; H U Schulz
Journal:  Eur J Clin Pharmacol       Date:  1977-10-14       Impact factor: 2.953
  10 in total
  1 in total

Review 1.  Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide.

Authors:  D Battino; M Estienne; G Avanzini
Journal:  Clin Pharmacokinet       Date:  1995-10       Impact factor: 6.447
  1 in total

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