Literature DB >> 119482

Acute intoxication with sodium valproate.

D W Chadwick, W J Cumming, I Livingstone, N E Cartlidge.   

Abstract

Two epileptic patients developed an acute toxic encephalopathy consisting of altered behavior, deteriorating seizure control, and confusion while taking sodium valproate alone. Serum valproate levels were greater than 100 microgram/ml in both. Toxic symptoms resolved when the dose of valproate was reduced, with a consequent fall in serum concentration of the drug.

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Year:  1979        PMID： 119482     DOI： 10.1002/ana.410060616

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  11 in total

1.  Valproic acid-associated encephalopathy.

Authors:  G L Jones; F Matsuo; J R Baringer; W H Reichert
Journal:  West J Med       Date:  1990-08

2.  Acute sodium valproate intoxication: occurrence of renal failure and treatment with haemoperfusion-haemodialysis.

Authors:  A M Roodhooft; K Van Dam; D Haentjens; G A Verpooten; K J Van Acker
Journal:  Eur J Pediatr       Date:  1990-02       Impact factor: 3.183

Review 3.  Effects of psychotropic drugs on seizure threshold.

Authors:  Francesco Pisani; Giancarla Oteri; Cinzia Costa; Giorgio Di Raimondo; Raoul Di Perri
Journal:  Drug Saf       Date:  2002       Impact factor: 5.606

Review 4.  Hepatotoxicity to sodium valproate: a review.

Authors:  P R Powell-Jackson; J M Tredger; R Williams
Journal:  Gut       Date:  1984-06       Impact factor: 23.059

5.  A case of valproate intoxication with excessive brain edema.

Authors:  G Hintze; H H Klein; H Prange; H Kreuzer
Journal:  Klin Wochenschr       Date:  1987-05-04

6.  Impairment of consciousness induced by valproate treatment following neurosurgical operation.

Authors:  J Landau; M Baulac; G Durand; A de Billy; J Philippon
Journal:  Acta Neurochir (Wien)       Date:  1993       Impact factor: 2.216

7.  Stuporous states or coma induced by the rapid administration of high doses of sodium valproate.

Authors:  H Gastaut; F Iemolo
Journal:  Ital J Neurol Sci       Date:  1982-10

8.  Comparison of the effectiveness of several formulations of sodium valproate: tablets, enteric-coated capsules, solutions and rectal capsules.

Authors:  D Battino; M Biraghi; C Cusi; A Nespolo; G Avanzini
Journal:  Ital J Neurol Sci       Date:  1982-10

Review 9.  Concentration-effect relationships of valproic acid.

Authors:  D W Chadwick
Journal:  Clin Pharmacokinet       Date:  1985 Mar-Apr       Impact factor: 6.447

10.  Sodium valproate "encephalopathy": report of three cases with generalised epilepsy.

Authors:  A Tartara; R Manni
Journal:  Ital J Neurol Sci       Date:  1985-03
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