Literature DB >> 6818955

Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes.

S Alemany, I Varela, J M Mato.   

Abstract

The addition of 1 microM-vasopressin or -angiotensin to isolated rat hepatocytes induced a fast transient inhibition of the rate of incorporation of [Me-3H]choline into phosphatidylcholine. The cationophore A23187 induced a similar inhibition of phosphatidylcholine synthesis. The addition of micromolar Ca2+ to rat liver microsomes inhibited the activity of CDP-choline: 1,2-diacylglycerol cholinephosphotransferase. This inhibition is due a decrease in the Vmax. of the enzyme without affecting the Km for CDP-choline. It is concluded that Ca2+ regulates phosphatidylcholine synthesis in rat liver.

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Year:  1982        PMID： 6818955      PMCID： PMC1153983          DOI： 10.1042/bj2080453

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  19 in total

1.  The activation of liver glycogen phosphorylase by angiotensin II.

Authors:  S Keppens; H De Wulf
Journal:  FEBS Lett       Date:  1976-10-01       Impact factor: 4.124

2.  Mechanism for selectively inhibiting the activation of cyclic nucleotide phosphodiesterase and adenylate cyclase by antipsychotic agents.

Authors:  B Weiss; R M Levin
Journal:  Adv Cyclic Nucleotide Res       Date:  1978

3.  Reciprocal relationship between uptake of Ca++ and biosynthesis of glycerolipids from sn-glycerol-3-phosphate by rat liver microsomes.

Authors:  C Soler-Argilaga; R L Russell; M Heimberg
Journal:  Biochem Biophys Res Commun       Date:  1977-10-10       Impact factor: 3.575

Review 4.  Phospholipid metabolism.

Authors:  W C McMurray; W L Magee
Journal:  Annu Rev Biochem       Date:  1972       Impact factor: 23.643

5.  cAMP analogues inhibit phosphatidylcholine biosynthesis in cultured rat hepatocytes.

Authors:  S L Pelech; P H Pritchard; D E Vance
Journal:  J Biol Chem       Date:  1981-08-25       Impact factor: 5.157

6.  Calmodulin modulates phospholipid methylation in Dictyostelium discoideum.

Authors:  M G Gil; S Alemany; D M Cao; J G Castano; J M Mato
Journal:  Biochem Biophys Res Commun       Date:  1980-06-30       Impact factor: 3.575

7.  Influence of glucagon on the synthesis of phosphatidylcholines and phosphatidylethanolamines in monolayer cultures of rat hepatocytes.

Authors:  M J Geelen; J E Groener; C G De Haas; L M Van Golde
Journal:  FEBS Lett       Date:  1979-09-01       Impact factor: 4.124

8.  Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substrates.

Authors:  R Sundler; B Akesson
Journal:  J Biol Chem       Date:  1975-05-10       Impact factor: 5.157

9.  Activation of phospholipid methyltransferase by glucagon in rat hepatocytes.

Authors:  J G Castaño; S Alemany; A Nieto; J M Mato
Journal:  J Biol Chem       Date:  1980-10-10       Impact factor: 5.157

10.  Calmodulin. Production of an antibody in rabbit and development of a radioimmunoassay.

Authors:  R W Wallace; W Y Cheung
Journal:  J Biol Chem       Date:  1979-07-25       Impact factor: 5.157
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  7 in total

1.  Biphasic modulation of choline uptake and phosphatidylcholine biosynthesis by vasopressin in rat cardiac myocytes.

Authors:  A S Man; E Lee; P C Choy
Journal:  Lipids       Date:  1994-01       Impact factor: 1.880

Review 2.  What is the function of phospholipid N-methylation?

Authors:  J M Mato; S Alemany
Journal:  Biochem J       Date:  1983-07-01       Impact factor: 3.857

3.  Inhibition of Cottonseed Choline- and Ethanolaminephosphotransferases by Calcium during Postgerminative Growth.

Authors:  K D Chapman; R N Trelease
Journal:  Plant Physiol       Date:  1990-08       Impact factor: 8.340

4.  Beta-adrenergic control of phosphatidylcholine synthesis by transmethylation in hepatocytes from juvenile, adult and adrenalectomized rats.

Authors:  D Marin-Cao; V Alvarez Chiva; J M Mato
Journal:  Biochem J       Date:  1983-12-15       Impact factor: 3.857

5.  Effects of vasopressin and corticosterone on fatty acid metabolism and on the activities of glycerol phosphate acyltransferase and phosphatidate phosphohydrolase in rat hepatocytes.

Authors:  A D Pollard; D N Brindley
Journal:  Biochem J       Date:  1984-01-15       Impact factor: 3.857

6.  Quantification of inositol phospholipid breakdown in isolated rat hepatocytes.

Authors:  C J Allan; J H Exton
Journal:  Biochem J       Date:  1993-03-15       Impact factor: 3.857

7.  A transient increase in diacylglycerols is associated with the action of vasopressin on hepatocytes.

Authors:  B P Hughes; K A Rye; L B Pickford; G J Barritt; A H Chalmers
Journal:  Biochem J       Date:  1984-09-01       Impact factor: 3.857
  7 in total

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