Literature DB >> 6251072

Activation of phospholipid methyltransferase by glucagon in rat hepatocytes.

J G Castaño, S Alemany, A Nieto, J M Mato.   

Abstract

Glucagon produces a time- and dose-dependent activation of phospholipid methyltransferase activity in isolated rat hepatocytes. Half-maximal effect is caused by a dose of glucagon of 1 x 10(-10) M. This activation is due to an increase of the Vmax value of the enzyme, without affecting the Km value for S-adenosylmethionine. Exogenous cyclic AMP added to isolated rat hepatocytes mimics the effect of glucagon, and the activation of phospholipid methyltransferase by a nonsaturating concentration of glucagon is spontaneously reversible within 40 min of incubation.

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Year:  1980        PMID： 6251072

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  18 in total

Review 1.  Biochemistry and pharmacology of S-adenosyl-L-methionine and rationale for its use in liver disease.

Authors:  R K Chawla; H L Bonkovsky; J T Galambos
Journal:  Drugs       Date:  1990       Impact factor: 9.546

2.  HLA-B18 is associated with decreased levels of isoproterenol-stimulated cAMP in lymphocytes.

Authors:  R P Erickson; G L Pairitz; J M Karolyi; J J Kapur; D J Odenheimer; J S Schultz; C F Sing
Journal:  Am J Hum Genet       Date:  1985-01       Impact factor: 11.025

3.  Tumor cell autocrine motility factor.

Authors:  L A Liotta; R Mandler; G Murano; D A Katz; R K Gordon; P K Chiang; E Schiffmann
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

4.  Purification of phospholipid methyltransferase from rat liver microsomal fraction.

Authors:  M A Pajares; M Villalba; J M Mato
Journal:  Biochem J       Date:  1986-08-01       Impact factor: 3.857

5.  Protein kinase C catalyses the phosphorylation and activation of rat liver phospholipid methyltransferase.

Authors:  M Villalba; M A Pajares; M F Renart; J M Mato
Journal:  Biochem J       Date:  1987-02-01       Impact factor: 3.857

Review 6.  Phospholipids and islet function.

Authors:  L Best; W J Malaisse
Journal:  Diabetologia       Date:  1983-10       Impact factor: 10.122

7.  Dopamine stimulation of phosphatidylcholine (lecithin) biosynthesis in rat brain neurons.

Authors:  C E Leprohon; J K Blusztajn; R J Wurtman
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

8.  Beta-adrenergic control of phosphatidylcholine synthesis by transmethylation in hepatocytes from juvenile, adult and adrenalectomized rats.

Authors:  D Marin-Cao; V Alvarez Chiva; J M Mato
Journal:  Biochem J       Date:  1983-12-15       Impact factor: 3.857

9.  Phospholipid methyltransferase activity in diabetic rat fat cells: effect of isoproterenol and insulin.

Authors:  G E Chiappe de Cingolani
Journal:  Mol Cell Biochem       Date:  1992-09-22       Impact factor: 3.396

10.  Inhibition of phospholipid methylation by a cytosolic factor.

Authors:  V Alvarez Chiva; J M Mato
Journal:  Biochem J       Date:  1984-03-01       Impact factor: 3.857
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