Literature DB >> 6818498

Spontaneous paroxysmal electroclinical patterns in rat: a model of generalized non-convulsive epilepsy.

M Vergnes, C Marescaux, G Micheletti, J Reis, A Depaulis, L Rumbach, J M Warter.   

Abstract

During quiet wakefulness of 63 adult Wistar rats, 24 exhibited synchronous paroxysmal bursts consisting of spikes and spike and wave discharges, recorded in the amygdala and frontoparietal cortex. Discharges were associated with a sudden immobility of the rat and rhythmic twitches of vibrissae or cervicofacial musculature. As soon as the phenomena stopped, the animal resumed its previous behavior. Paroxysmal electroclinical attacks could be observed as long as the animal survived. Similar electrical discharges have been observed previously in rodents by other authors and interpreted as an epileptic phenomenon. Preliminary pharmacological results confirm this interpretation and emphasize the similarity between our findings and the human petit mal epilepsy.

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Year:  1982        PMID： 6818498     DOI： 10.1016/0304-3940(82)90136-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  38 in total

Review 1.  Electrical stimulation for epilepsy: experimental approaches.

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Journal:  Neurosurg Clin N Am       Date:  2011-10       Impact factor: 2.509

Review 2.  A brief history on the oscillating roles of thalamus and cortex in absence seizures.

Authors:  Massimo Avoli
Journal:  Epilepsia       Date:  2012-02-23       Impact factor: 5.864

3.  Spike-wave discharges: absence or not, a common finding in common laboratory rats.

Authors:  Kevin M Kelly
Journal:  Epilepsy Curr       Date:  2004 Sep-Oct       Impact factor: 7.500

4.  Intracellular activity of cortical and thalamic neurones during high-voltage rhythmic spike discharge in Long-Evans rats in vivo.

Authors:  Pierre-Olivier Polack; Stéphane Charpier
Journal:  J Physiol       Date:  2006-01-12       Impact factor: 5.182

Review 5.  The role of GABAB mechanisms in animal models of absence seizures.

Authors:  S J Caddick; D A Hosford
Journal:  Mol Neurobiol       Date:  1996-08       Impact factor: 5.590

6.  Impact of strain, sex, and estrous cycle on gamma butyrolactone-evoked absence seizures in rats.

Authors:  Victor R Santos; Ihori Kobayashi; Robert Hammack; Gregory Danko; Patrick A Forcelli
Journal:  Epilepsy Res       Date:  2018-09-18       Impact factor: 3.045

7.  Genetics of absence epilepsy in rats.

Authors:  B W Peeters; J M Kerbusch; E L van Luijtelaar; J M Vossen; A M Coenen
Journal:  Behav Genet       Date:  1990-05       Impact factor: 2.805

Review 8.  New avenues for anti-epileptic drug discovery and development.

Authors:  Wolfgang Löscher; Henrik Klitgaard; Roy E Twyman; Dieter Schmidt
Journal:  Nat Rev Drug Discov       Date:  2013-09-20       Impact factor: 84.694

9.  Semidominant expression of absence-like seizure in tremor rats.

Authors:  T Higashiguchi; T Serikawa; T Yamada; K Kogishi; A Kondo; J Yamada
Journal:  Behav Genet       Date:  1991-11       Impact factor: 2.805

10.  Development of spike-wave seizures in C3H/HeJ mice.

Authors:  Damien J Ellens; Ellie Hong; Kathryn Giblin; Matthew J Singleton; Chhitij Bashyal; Dario J Englot; Asht M Mishra; Hal Blumenfeld
Journal:  Epilepsy Res       Date:  2009-05-05       Impact factor: 3.045
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