Literature DB >> 2116125

Genetics of absence epilepsy in rats.

B W Peeters1, J M Kerbusch, E L van Luijtelaar, J M Vossen, A M Coenen.   

Abstract

All rats of the WAG inbred strain show electrophysiological and behavioral phenomena reminiscent of human absence epilepsy. To study the genetic architecture of this kind of epilepsy, WAG rats were cross bred with inbred ACI rats which show no signs of epilepsy. Number and duration of spike-wave discharges per hour were determined from 24-h recordings of cortical EEG in parental strains and reciprocal F1 hybrids. All hybrids showed spike-wave discharges, indicating complete dominance for occurrence, but different genetic backgrounds were suggested for number and duration of the phenomena. These results imply that more than one gene is involved in absence epilepsy. Some genes determine the occurrence, while others may manipulate the actual number and duration of the epileptic phenomena.

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Year:  1990        PMID： 2116125     DOI： 10.1007/bf01065569

Source DB:  PubMed          Journal:  Behav Genet        ISSN： 0001-8244            Impact factor:   2.805


  12 in total

1.  Genetics of convulsive disorders. II. Genetic and electroencephalographic studies in centrencephalic epilepsy.

Authors:  K METRAKOS; J D METRAKOS
Journal:  Neurology       Date:  1961-06       Impact factor: 9.910

2.  The heredity of epilepsy as told by relatives and twins.

Authors:  W G LENNOX
Journal:  J Am Med Assoc       Date:  1951-06-09

3.  Two types of electrocortical paroxysms in an inbred strain of rats.

Authors:  E L van Luijtelaar; A M Coenen
Journal:  Neurosci Lett       Date:  1986-10-20       Impact factor: 3.046

4.  Maternal buffering of rodent genotypic responses to stress: a complex genotype-environment interaction.

Authors:  D W Fulker
Journal:  Behav Genet       Date:  1970-05       Impact factor: 2.805

5.  Circadian rhythmicity in absence epilepsy in rats.

Authors:  E L Van Luijtelaar; A M Coenen
Journal:  Epilepsy Res       Date:  1988 Sep-Oct       Impact factor: 3.045

6.  Genetic factors in spike-wave absences.

Authors:  H Doose; H Gerken; T Horstmann; E Völzke
Journal:  Epilepsia       Date:  1973-03       Impact factor: 5.864

Review 7.  Genetic heterogeneity in the epilepsies.

Authors:  V E Anderson; W A Hauser; S S Rich
Journal:  Adv Neurol       Date:  1986

8.  Spontaneous paroxysmal electroclinical patterns in rat: a model of generalized non-convulsive epilepsy.

Authors:  M Vergnes; C Marescaux; G Micheletti; J Reis; A Depaulis; L Rumbach; J M Warter
Journal:  Neurosci Lett       Date:  1982-11-16       Impact factor: 3.046

9.  The WAG/Rij rat model for absence epilepsy: age and sex factors.

Authors:  A M Coenen; E L Van Luijtelaar
Journal:  Epilepsy Res       Date:  1987-09       Impact factor: 3.045

10.  An EEG averaging technique for automated sleep-wake stage identification in the rat.

Authors:  E L van Luijtelaar; A M Coenen
Journal:  Physiol Behav       Date:  1984-11
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  4 in total

Review 1.  A brief history on the oscillating roles of thalamus and cortex in absence seizures.

Authors:  Massimo Avoli
Journal:  Epilepsia       Date:  2012-02-23       Impact factor: 5.864

2.  Cellular-synaptic generation of sleep spindles, spike-and-wave discharges, and evoked thalamocortical responses in the neocortex of the rat.

Authors:  A Kandel; G Buzsáki
Journal:  J Neurosci       Date:  1997-09-01       Impact factor: 6.167

Review 3.  Animal models of absence epilepsies: what do they model and do sex and sex hormones matter?

Authors:  Gilles van Luijtelaar; Filiz Yilmaz Onat; Martin J Gallagher
Journal:  Neurobiol Dis       Date:  2014-08-15       Impact factor: 5.996

4.  Genetics of spike-wave discharges in the electroencephalogram (EEG) of the WAG/Rij inbred rat strain: a classical mendelian crossbreeding study.

Authors:  B W Peeters; J M Kerbusch; A M Coenen; J M Vossen; E L van Luijtelaar
Journal:  Behav Genet       Date:  1992-05       Impact factor: 2.805
  4 in total

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