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Literature DB >> 6815697

Opposite effects of chlordiazepoxide and serotonin receptor antagonists on morphine-induced locomotor stimulation in mice.

Abstract

Chlordiazepoxide and two serotonin receptor antagonists showed opposite effects when tested for their influence on morphine-induced locomotor stimulation in mice. Chlordiazepoxide enhanced morphine-induced hyperactivity, which was antagonized by cyproheptadine and mianserin. The results indicate that the enhancement of morphine-induced locomotor stimulation is not attributable to an antiserotonergic action of the benzodiazepine compound.

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Year: 1982 PMID： 6815697 DOI： 10.1007/bf00470588

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

19 in total

1. Antagonism by mianserin and classical alpha-adrenoceptor blocking drugs of some cardiovascular and behavioral effects of clonidine.

Authors: R D Robson; M J Antonaccio; J K Saelens; J Liebman
Journal: Eur J Pharmacol Date: 1978-02-15 Impact factor: 4.432

2. Different central effects of the 5-HT antagonists mianserine and cyproheptadine.

Authors: H van Riezen
Journal: Arch Int Pharmacodyn Ther Date: 1972-08

3. Mianserin hydrochloride: peripheral and central effects in relation to antagonism against 5-hydroxytryptamine and tryptamine.

Authors: B B Vargaftig; J L Coignet; C J de Vos; H Grijsen; I L Bonta
Journal: Eur J Pharmacol Date: 1971 Nov-Dec Impact factor: 4.432

Opposite effects of chlordiazepoxide and serotonin receptor antagonists on morphine-induced locomotor stimulation in mice.

1. Antagonism by mianserin and classical alpha-adrenoceptor blocking drugs of some cardiovascular and behavioral effects of clonidine.

2. Different central effects of the 5-HT antagonists mianserine and cyproheptadine.

3. Mianserin hydrochloride: peripheral and central effects in relation to antagonism against 5-hydroxytryptamine and tryptamine.

4. Lack of morphine-induced hyperactivity in C57BL/6 mice following striatal kainic acid lesions.

5. Lithium and alpha-methyl-p-tyrosine prevent "manic" activity in rodents.

6. Benzodiazepines: behavioral and neurochemical mechanisms.

7. The central antiserotonergic action of mianserin.

8. Monoamine mediation of the morphine-induced activation of mice.

9. Benzodiazepines: anxiety-reducing activity by reduction of serotonin turnover in the brain.

10. Role of the periaqueductal gray substance in the antianxiety action of benzodiazepines.

1. Antihistaminics enhance morphine-, but not amphetamine- and scopolamine-induced hyperactivity in mice.