Literature DB >> 17305

Benzodiazepines: behavioral and neurochemical mechanisms.

L Stein, J D Belluzzi, C D Wise.   

Abstract

The therapeutic effects of benzodiazepines in psychoneurosis may depend in part on their ability to release or disinhibit a patient's anxiety-suppressed gratification-seeking behavior. Benzodiazepines may disinhibit behavior by reducing the activity of serotonin (and possibly acetylcholine) neurons in the brain's "punishment" system. Reduction of serotonin transmission may be due to a facilitation of gamma-aminobutyric acid (GABA)-mediated presynaptic inhibition at the serotonin nerve terminal.

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Year:  1977        PMID： 17305     DOI： 10.1176/ajp.134.6.665

Source DB:  PubMed          Journal:  Am J Psychiatry        ISSN： 0002-953X            Impact factor:   18.112


  19 in total

1.  Behavioral evidence for the role of noradrenaline in putative anxiolytic and sedative effects of benzodiazepines.

Authors:  X M Yang; Z P Luo; J H Zhou
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

2.  The influence of psychotropic drugs on the ultrasonic calling of mouse pups.

Authors:  D Benton; K Nastiti
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

3.  The staircase test: some evidence of nonspecificity for anxiolytics.

Authors:  G T Pollard; J L Howard
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

4.  Benzodiazepines reduce the tolerance to reward delay in rats.

Authors:  M H Thiébot; C Le Bihan; P Soubrié; P Simon
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

5.  Picrotoxin-diazepam interaction in a behavioural schedule of differential reinforcement of low rates.

Authors:  P Soubrié; M H Thiébot; A Jobert
Journal:  Experientia       Date:  1978-12-15

6.  Dexmedetomidine synergism with midazolam in the elevated plus-maze test in rats.

Authors:  M Salonen; E S Onaivi; M Maze
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

7.  5-HT1A receptor blockade reverses GABA(A) receptor alpha3 subunit-mediated anxiolytic effects on stress-induced hyperthermia.

Authors:  Christiaan H Vinkers; Ruud van Oorschot; S Mechiel Korte; Berend Olivier; Lucianne Groenink
Journal:  Psychopharmacology (Berl)       Date:  2010-06-10       Impact factor: 4.530

8.  Differential modulation of extracellular levels of 5-hydroxytryptamine in the rat frontal cortex by (R)- and (S)-zacopride.

Authors:  N M Barnes; C H Cheng; B Costall; J Ge; R J Naylor
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739

9.  The profiles of interaction of yohimbine with anxiolytic and putative anxiolytic agents to modify 5-HT release in the frontal cortex of freely-moving rats.

Authors:  C H Cheng; B Costall; J Ge; R J Naylor
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

10.  Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5-HT1A receptors negatively coupled with adenylate cyclase in hippocampal neurons.

Authors:  J Bockaert; A Dumuis; R Bouhelal; M Sebben; R N Cory
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-05       Impact factor: 3.000
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