Literature DB >> 6812567

Localization of cyclo-oxygenase and thromboxane synthetase in human platelet intracellular membranes.

F Carey, S Menashi, N Crawford.   

Abstract

Platelet mixed membrane fractions can be separated into discrete vesicle subpopulations of surface and intracellular origin. Intracellular membrane vesicles are the predominant site of phospholipid-modifying enzymes that liberate arachidonic acid. We report the selective enrichment in intracellular membranes of cyclo-oxygenase and thromboxane synthetase activities. Surface membrane fractions show no such enrichment. These results suggest that a sequence of activities leading to the biosynthesis of thromboxane from arachidonate is associated with the intracellular membrane elements known as dense tubular membranes.

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Year:  1982        PMID： 6812567      PMCID： PMC1158429          DOI： 10.1042/bj2040847

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Synthesis of platelet-aggregating factor by human platelet microsomes.

Authors:  P P Ho; C P Walters; R G Hermann
Journal:  Biochem Biophys Res Commun       Date:  1976-03-08       Impact factor: 3.575

2.  Solubilization and resolution of thromboxane synthesizing system from microsomes of bovine blood platelets.

Authors:  T Yoshimoto; S Yamamoto; M Okuma; O Hayaishi
Journal:  J Biol Chem       Date:  1977-08-25       Impact factor: 5.157

3.  Enzymatic preparation of prostaglandin endoperoxides.

Authors:  F B Ubatuba; S Moncada
Journal:  Prostaglandins       Date:  1977-06

4.  Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides.

Authors:  P Needleman; S Moncada; S Bunting; J R Vane; M Hamberg; B Samuelsson
Journal:  Nature       Date:  1976-06-17       Impact factor: 49.962

Review 5.  The platelet dense tubular system: its relationship to prostaglandin synthesis and calcium flux.

Authors:  J M Gerrard; J G White; D A Peterson
Journal:  Thromb Haemost       Date:  1978-10-31       Impact factor: 5.249

6.  Resolution of prostaglandin endoperoxide synthase and thromboxane synthase of human platelets.

Authors:  S Hammarström; P Falardeau
Journal:  Proc Natl Acad Sci U S A       Date:  1977-09       Impact factor: 11.205

7.  Isolation and properties of intermediates in prostaglandin biosynthesis.

Authors:  D H Nugteren; E Hazelhof
Journal:  Biochim Biophys Acta       Date:  1973-12-20

8.  Localization of platelet prostaglandin production in the platelet dense tubular system.

Authors:  J M Gerrard; J G White; G H Rao; D Townsend
Journal:  Am J Pathol       Date:  1976-05       Impact factor: 4.307

9.  Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis.

Authors:  M Hamberg; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205

10.  Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Authors:  M Hamberg; J Svensson; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205
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  14 in total

1.  A monoclonal antibody (PL/IM 430) to human platelet intracellular membranes which inhibits the uptake of Ca2+ without affecting the Ca2+ +Mg2+-ATPase.

Authors:  N Hack; J M Wilkinson; N Crawford
Journal:  Biochem J       Date:  1988-03-01       Impact factor: 3.857

2.  Characterization of the calcium-sequestering process associated with human platelet intracellular membranes isolated by free-flow electrophoresis.

Authors:  S Menashi; K S Authi; F Carey; N Crawford
Journal:  Biochem J       Date:  1984-09-01       Impact factor: 3.857

3.  Subcellular localization and some properties of lipoxygenase activity in human blood platelets.

Authors:  M Lagarde; M Croset; K S Authi; N Crawford
Journal:  Biochem J       Date:  1984-09-01       Impact factor: 3.857

4.  Two-dimensional polyacrylamide-gel electrophoresis of the proteins and glycoproteins of purified human platelet surface and intracellular membranes.

Authors:  N Hack; N Crawford
Journal:  Biochem J       Date:  1984-08-15       Impact factor: 3.857

Review 5.  Platelet activation in normo- and hyperlipoproteinemias.

Authors:  J Nimpf; H Wurm; G M Kostner; T Kenner
Journal:  Basic Res Cardiol       Date:  1986 Sep-Oct       Impact factor: 17.165

6.  The inhibition of platelet cyclo-oxygenase by aspirin is associated with the acetylation of a 72kDa polypeptide in the intracellular membranes.

Authors:  N Hack; F Carey; N Crawford
Journal:  Biochem J       Date:  1984-10-01       Impact factor: 3.857

7.  Ca2+ release from platelet intracellular stores by thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone: relationship to Ca2+ pools and relevance in platelet activation.

Authors:  K S Authi; S Bokkala; Y Patel; V V Kakkar; F Munkonge
Journal:  Biochem J       Date:  1993-08-15       Impact factor: 3.857

8.  Metabolic and functional consequences of introducing inositol 1,4,5-trisphosphate into saponin-permeabilized human platelets.

Authors:  K S Authi; B J Evenden; N Crawford
Journal:  Biochem J       Date:  1986-02-01       Impact factor: 3.857

9.  Production of prostaglandins and thromboxane by isolated cells from intracranial tumours.

Authors:  C Cooper; H G Jones; R O Weller; V Walker
Journal:  J Neurol Neurosurg Psychiatry       Date:  1984-06       Impact factor: 10.154

10.  A unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets.

Authors:  F Chevy; C Wolf; O Colard
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880
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