Literature DB >> 6812124

3H-Imipramine high-affinity binding sites in rat brain. Effects of imipramine and lithium.

P Plenge, E T Mellerup.   

Abstract

The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five weeks of lithium treatment decreased the number of binding sites, but had no effect on the affinity constants. Long-term imipramine treatment had no effect on the number of binding sites but apparently decreased the affinity. The latter effect was probably due to imipramine remaining in the membrane preparation.

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Year:  1982        PMID： 6812124     DOI： 10.1007/bf00436105

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  10 in total

1.  Lithium effects on haloperidol-induced pre- and postsynaptic dopamine receptor supersensitivity.

Authors:  T Verimer; D B Goodale; J P Long; J R Flynn
Journal:  J Pharm Pharmacol       Date:  1980-09       Impact factor: 3.765

2.  Demonstration of specific "high affinity" binding sites for [3H] imipramine on human platelets.

Authors:  S M Paul; M Rehavi; P Skolnick; F K Goodwin
Journal:  Life Sci       Date:  1980-03-24       Impact factor: 5.037

3.  Chronic lithium reduces [3H]spiroperidol binding in rat striatum.

Authors:  J E Rosenblatt; A Pert; B Layton; W E Bunney
Journal:  Eur J Pharmacol       Date:  1980-10-17       Impact factor: 4.432

4.  Localisation of tricyclic antidepressant binding sites on serotonin nerve terminals.

Authors:  M Sette; R Raisman; M Briley; S Z Langer
Journal:  J Neurochem       Date:  1981-07       Impact factor: 5.372

5.  Demonstration of specific high affinity binding sites for [3H] imipramine in human brain.

Authors:  M Rehavi; S M Paul; P Skolnick; F K Goodwin
Journal:  Life Sci       Date:  1980-06-30       Impact factor: 5.037

6.  A simplification of the protein assay method of Lowry et al. which is more generally applicable.

Authors:  G L Peterson
Journal:  Anal Biochem       Date:  1977-12       Impact factor: 3.365

7.  Specific tricyclic antidepressant binding sites in rat brain characterised by high-affinity 3H-imipramine binding.

Authors:  R Raisman; M S Briley; S Z Langer
Journal:  Eur J Pharmacol       Date:  1980-02       Impact factor: 4.432

8.  Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport.

Authors:  J Talvenheimo; P J Nelson; G Rudnick
Journal:  J Biol Chem       Date:  1979-06-10       Impact factor: 5.157

9.  Lithium reduces the number of acetylcholine receptors in skeletal muscle.

Authors:  A Pestronk; D B Drachman
Journal:  Science       Date:  1980-10-17       Impact factor: 47.728

10.  Lithium: effects on serotonin receptors in rat brain.

Authors:  S Treiser; K J Kellar
Journal:  Eur J Pharmacol       Date:  1980-06-13       Impact factor: 4.432
  10 in total
  5 in total

1.  Reduced Bmax of [3H]-imipramine binding to platelets of depressed patients free of previous medication with 5HT uptake inhibitors.

Authors:  M F Poirier; C Benkelfat; H Loo; D Sechter; E Zarifian; A M Galzin; S Z Langer
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

Review 2.  Antidepressants and serotonergic neurotransmission: an integrative review.

Authors:  P Willner
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

Review 3.  Lithium and serotonin function: implications for the serotonin hypothesis of depression.

Authors:  L H Price; D S Charney; P L Delgado; G R Heninger
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

4.  Unaltered 5-HT- and desipramine-sensitive [3H]imipramine binding and [3H]5-HT uptake in rat brain after chronic imipramine and norzimeldine treatment.

Authors:  J Marcusson; I T Bäckström; S B Ross
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

5.  3H-imipramine and 3H-cyano-imipramine binding in rat brain tissue: effect of long-term antidepressant administration.

Authors:  C Gentsch; M Lichtsteiner; H Feer
Journal:  J Neural Transm       Date:  1984       Impact factor: 3.575
  5 in total

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