| Literature DB >> 6747623 |
C Gentsch, M Lichtsteiner, H Feer.
Abstract
3H-imipramine and 3H-cyano-imipramine binding was determined in brain homogenates of rats which had been treated for 21 days with imipramine or desimipramine. When compared to control animals, long-term administration of these antidepressants did not induce any alteration in the maximal number of 3H-imipramine or 3H-cyano-imipramine binding sites. However, a transient increase in the apparent dissociation constant was observed. Such findings are discussed in respect to previous studies, which have been highly contraversial.Entities:
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Year: 1984 PMID： 6747623 DOI： 10.1007/BF01255595
Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575