| Literature DB >> 6811667 |
K W Beisel, Y M Kong, K S Babu, C S David, N R Rose.
Abstract
Experiments were conducted to investigate the non-H-2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB background in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H-2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H-2 haplotypes. These observations show that non-H-2 gene(s) influences EAT, in addition to genes in the MHC.Entities:
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Year: 1982 PMID： 6811667 DOI： 10.1111/j.1744-313x.1982.tb00981.x
Source DB: PubMed Journal: J Immunogenet ISSN： 0305-1811