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Literature DB >> 6809090

Effect of ETYA and BW 755c on arachidonate-induced contractions in the guinea-pig isolated trachea.

Abstract

1. Arachidonic acid caused larger contractions to indomethacin-tested guinea-pig trachea than in control tracheae. 2. No change in contractions was obtained in tracheae treated with 5,8, 11, 14, eicosatetraynoic acid (ETYA 10 micro M). 3. ETYA (100 micro M) blocked the effect of indomethacin on arachidonic acid-induced responses. Likewise BW 755c (113 micro M) reversed the effect of indomethacin. 4. The results show that arachidonate lipoxygenase products may be responsible for the contractile responses seen in the presence of indomethacin.

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Year: 1982 PMID： 6809090 PMCID： PMC2071828 DOI： 10.1111/j.1476-5381.1982.tb09250.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

11 in total

1. On the formation of thromboxane B2 and 12l-hydroxy-5,8,10,14-eicosatetraenoic acid (12 ho-20:4) in tissues from the guinea pig.

Authors: M Hamberg
Journal: Biochim Biophys Acta Date: 1976-06-22

2. The effects of arachidonic acid and non-steroidal anti-inflammatory drugs on intrapulmonary airways of the guinea-pig.

Authors: T P Clay; D C Fenske
Journal: Br J Pharmacol Date: 1984-02 Impact factor: 8.739

3. Mediators of arachidonic acid-induced contractions of indomethacin-treated guinea-pig airways: leukotrienes C4 and D4.

Authors: J F Burka; M H Saad
Journal: Br J Pharmacol Date: 1984-03 Impact factor: 8.739

4. Propranolol-induced airway hyperreactivity in guinea-pigs.

Authors: U M Ney
Journal: Br J Pharmacol Date: 1983-08 Impact factor: 8.739

5. Pharmacological modulation of responses of guinea-pig airways contracted with arachidonic acid.

Authors: J F Burka
Journal: Br J Pharmacol Date: 1985-06 Impact factor: 8.739

5 in total

Effect of ETYA and BW 755c on arachidonate-induced contractions in the guinea-pig isolated trachea.

1. On the formation of thromboxane B2 and 12l-hydroxy-5,8,10,14-eicosatetraenoic acid (12 ho-20:4) in tissues from the guinea pig.

2. Clinical patterns of hypersensitivity to nonsteroidal anti-inflammatory drugs and their pathogenesis.

3. Enzyme inhibition by acetylenic compounds.

4. Evidence for lipoxygenase pathway involvement in allergic tracheal contraction.

5. A possible role for lipoxygenase products as regulators of airway smooth muscle reactivity.

6. The metabolism of arachidonic acid in the isolated tracheal and lung strip preparations of guinea-pigs.

7. The effects of arachidonic acid, indomethacin and SC-19220 on guinea-pig tracheal muscle tone.

8. Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs.

9. Anaphylaxis in guinea-pig peripheral airways in vitro.

10. Enhancement of anaphylactic mediator release from guinea-pig perfused lungs by fatty acid hydroperoxides.

1. A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.

2. The effects of arachidonic acid and non-steroidal anti-inflammatory drugs on intrapulmonary airways of the guinea-pig.

3. Mediators of arachidonic acid-induced contractions of indomethacin-treated guinea-pig airways: leukotrienes C4 and D4.

4. Propranolol-induced airway hyperreactivity in guinea-pigs.

5. Pharmacological modulation of responses of guinea-pig airways contracted with arachidonic acid.