Literature DB >> 6777006

A possible role for lipoxygenase products as regulators of airway smooth muscle reactivity.

J J Adcock, L G Garland.   

Abstract

The size of guinea-pig isolated tracheal contractions induced by histamine was substantially augmented by pretreatment with the cyclo-oxygenase inhibitor, indomethacin. However, compounds which inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid metabolism not only did not augment histamine-induced contractions of the guinea-pig trachea, but also completely reversed the increased reactivity to histamine produced by indomethacin. The SRS-A (slow reacting substance of anaphylaxis) antagonist, FPL55712, and the anti-allergic drug, cromoglycate, had no effect on the augmentation of histamine-induced contractions by indomethacin.

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Year:  1980        PMID： 6777006      PMCID： PMC2044254          DOI： 10.1111/j.1476-5381.1980.tb07886.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  Comparison of respiratory and cardiovascular effects of isoproterenol, propranolol, and practolol in asthmatic and normal subjects.

Authors:  U Y Ryo; R G Townley
Journal:  J Allergy Clin Immunol       Date:  1976-01       Impact factor: 10.793

2.  Selective inhibitor of slow reacting substance of anaphylaxis.

Authors:  J Augstein; J B Farmer; T B Lee; P Sheard; M L Tattersall
Journal:  Nat New Biol       Date:  1973-10-17

3.  Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs.

Authors:  J Orehek; J S Douglas; A Bouhuys
Journal:  J Pharmacol Exp Ther       Date:  1975-09       Impact factor: 4.030

4.  Bronchial hyperreactivity to prostaglandin F 2 and histamine in patients with asthma.

Authors:  A A Mathé; P Hedqvist; A Holmgren; N Svanborg
Journal:  Br Med J       Date:  1973-01-27

5.  The mechanism of enhancement by fatty acid hydroperoxides of anaphylactic mediator release.

Authors:  J J Adcock; L G Garland; S Moncada; J A Salmon
Journal:  Prostaglandins       Date:  1978-08

6.  Enhancement of anaphylactic mediator release from guinea-pig perfused lungs by fatty acid hydroperoxides.

Authors:  J J Adcock; L G Garland; S Moncada; J A Salmon
Journal:  Prostaglandins       Date:  1978-08

7.  Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

Authors:  R C Murphy; S Hammarström; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205
  7 in total
  20 in total

1.  Proceedings of the Fiftieth Anniversary Meeting of the British Pharmacological Society, University of Oxford, 16-18 September 1981. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1981-12       Impact factor: 8.739

2.  Induction in guinea-pigs of airway hyperreactivity and decreased lung beta-adrenoceptor number by 15-hydroperoxy-arachidonic acid.

Authors:  G Folkerts; F P Nijkamp; A J van Oosterhout
Journal:  Br J Pharmacol       Date:  1983-12       Impact factor: 8.739

3.  Sequential histamine inhalations cause increased bronchial histamine reactivity in guinea pigs: role of platelets, thromboxanes and prostacyclin.

Authors:  W Dorsch; C Hintschich; J Neuhauser; J Weber
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-09       Impact factor: 3.000

4.  Proceedings of the British Pharmacological Society. Cardiff, 10th-12th April, 1985. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1985-06       Impact factor: 8.739

5.  Prostaglandin synthesis inhibitors: effect on angiotensin II- and oxytocin-induced contractions in rat uterine smooth muscle.

Authors:  M M Hall
Journal:  Br J Pharmacol       Date:  1983-05       Impact factor: 8.739

6.  Prevention of allergen-induced bronchial obstruction in sensitized guinea pigs by crude alcoholic onion extract.

Authors:  W Dorsch; J Weber
Journal:  Agents Actions       Date:  1984-06

7.  The effects of arachidonic acid and non-steroidal anti-inflammatory drugs on intrapulmonary airways of the guinea-pig.

Authors:  T P Clay; D C Fenske
Journal:  Br J Pharmacol       Date:  1984-02       Impact factor: 8.739

8.  Pharmacological studies into cyclo-oxygenase, lipoxygenase and phospholipase in smooth muscle contraction in the isolated trachea.

Authors:  H W Mitchell
Journal:  Br J Pharmacol       Date:  1984-07       Impact factor: 8.739

9.  Propranolol-induced airway hyperreactivity in guinea-pigs.

Authors:  U M Ney
Journal:  Br J Pharmacol       Date:  1983-08       Impact factor: 8.739

10.  Indomethacin enhances the effect of histamine on airways resistance in the anaesthetized guinea-pig.

Authors:  H W Mitchell
Journal:  Br J Pharmacol       Date:  1983-10       Impact factor: 8.739
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